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Calattini S., Betsem E., Bassot S., Chevalier S. A., Mahieux R., Froment Alain, Gessain A. New strain of Human T Lymphotropic Virus (HTLV) type 3 in a pygmy from Cameroon with peculiar HTLV serologic results. journal of infectious diseases, 2007, 199 (4), p. 561-564.

Lien direct chez l'éditeur doi:10.1086/596206

En Libre Accès sur HAL http://hal.archives-ouvertes.fr/hal-00358082/en/

TitreNew strain of Human T Lymphotropic Virus (HTLV) type 3 in a pygmy from Cameroon with peculiar HTLV serologic results
Année de publication2007
Type de documentArticle référencé dans le Web of Science : 000262802200013
AuteursCalattini S., Betsem E., Bassot S., Chevalier S. A., Mahieux R., Froment Alain, Gessain A.
Sourcejournal of infectious diseases, 2007, 199 (4), p. 561-564.
RésuméA search for human T lymphotropic virus (HTLV) types 1 and 2 and related viruses was performed by serological and molecular means on samples obtained from 421 adult villagers from the southern Cameroon forest areas. One individual (a 56-year-old Baka Pygmy hunter) was found to be HTLV-3 infected; however, there was a low proviral load in blood cells. Complete sequence analysis of this virus (HTLV-3(Lobak18)) indicated a close relationship to human HTLV-3(Pyl43) and simian STLV-3(CTO604) strains. Plasma samples from Lobak18, the HTLV-3 infected individual, exhibited a peculiar "HTLV-2-like" pattern on Western blot analysis and were serologically untypeable by line immunoassay. These results were different from those for the 2 previously reported HTLV-3 strains, raising questions about serological confirmation of infection with such retroviruses.
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