Calattini S., Betsem E., Bassot S., Chevalier S. A., Mahieux R., Froment Alain, Gessain A. (2009). New strain of Human T Lymphotropic Virus (HTLV) type 3 in a pygmy from Cameroon with peculiar HTLV serologic results. journal of Infectious Diseases, 199 (4), p. 561-564.
Titre du document
New strain of Human T Lymphotropic Virus (HTLV) type 3 in a pygmy from Cameroon with peculiar HTLV serologic results
Calattini S., Betsem E., Bassot S., Chevalier S. A., Mahieux R., Froment Alain, Gessain A.
Source
journal of Infectious Diseases, 2009,
199 (4), p. 561-564
A search for human T lymphotropic virus (HTLV) types 1 and 2 and related viruses was performed by serological and molecular means on samples obtained from 421 adult villagers from the southern Cameroon forest areas. One individual (a 56-year-old Baka Pygmy hunter) was found to be HTLV-3 infected; however, there was a low proviral load in blood cells. Complete sequence analysis of this virus (HTLV-3(Lobak18)) indicated a close relationship to human HTLV-3(Pyl43) and simian STLV-3(CTO604) strains. Plasma samples from Lobak18, the HTLV-3 infected individual, exhibited a peculiar "HTLV-2-like" pattern on Western blot analysis and were serologically untypeable by line immunoassay. These results were different from those for the 2 previously reported HTLV-3 strains, raising questions about serological confirmation of infection with such retroviruses.
