Wobudeya E., Nanfuka M., Nguyet Mhtn, Taguebue J. V., Moh R., Breton G., Khosa C., Borand L., Mwanga-Amumpaire J., Mustapha A., Nolna S. K., Komena E., Mugisha J. R., Natukunda N., Dim B., de Lauzanne A., Cumbe S., Balestre E., Poublan J., Lounnas Manon, Ngu E., Joshi B., Norval P. Y., Terquiem E. L., Turyahabwe S., Foray L., Sidibé S., Albert K. K., Manhiça I., Sekadde M., Detjen A., Verkuijl S., Mao T. E., Orne-Gliemann J., Bonnet Maryline, Marcy Olivier. (2024). Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study. Eclinicalmedicine, 70, 102527 [12 p.].
Titre du document
Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study
Année de publication
2024
Auteurs
Wobudeya E., Nanfuka M., Nguyet Mhtn, Taguebue J. V., Moh R., Breton G., Khosa C., Borand L., Mwanga-Amumpaire J., Mustapha A., Nolna S. K., Komena E., Mugisha J. R., Natukunda N., Dim B., de Lauzanne A., Cumbe S., Balestre E., Poublan J., Lounnas Manon, Ngu E., Joshi B., Norval P. Y., Terquiem E. L., Turyahabwe S., Foray L., Sidibé S., Albert K. K., Manhiça I., Sekadde M., Detjen A., Verkuijl S., Mao T. E., Orne-Gliemann J., Bonnet Maryline, Marcy Olivier
Source
Eclinicalmedicine, 2024,
70, 102527 [12 p.]
Background Childhood tuberculosis (TB) remains underdiagnosed largely because of limited awareness and poor access to all or any of specimen collection, molecular testing, clinical evaluation, and chest radiography at low levels of care. Decentralising childhood TB diagnostics to district hospitals (DH) and primary health centres (PHC) could improve case detection. Methods We conducted an operational research study using a pre-post intervention cross-sectional study design in 12 DHs and 47 PHCs of 12 districts across Cambodia, Cameroon, C & ocirc;te d'Ivoire, Mozambique, Sierra Leone and Uganda. The intervention included 1) a comprehensive diagnosis package at patient-level with tuberculosis screening for all sick children and young adolescents <15 years, and clinical evaluation, Xpert Ultra-testing on respiratory and stool samples, and chest radiography for children with presumptive TB, and 2) two decentralisation approaches (PHC-focused or DH-focused) to which districts were randomly allocated at country level. We collected aggregated and individual data. We compared the proportion of tuberculosis detection in children and young adolescents <15 years pre-intervention (01 August 2018-30 November 2019) versus during intervention (07 March 2020-30 September 2021), overall and by decentralisation approach. This study is registered with ClinicalTrials.gov, NCT04038632. Findings TB was diagnosed in 217/255,512 (0.08%) children and young adolescent <15 years attending care pre-intervention versus 411/179,581 (0.23%) during intervention, (OR: 3.59 [95% CI 1.99-6.46], p-value<0.0001; p-value = 0.055 after correcting for over-dispersion). In DH-focused districts, TB diagnosis was 80/122,570 (0.07%) versus 302/86,186 (0.35%) (OR: 4.07 [1.86-8.90]; p-value = 0.0005; p-value = 0.12 after correcting for over-dispersion); and 137/132,942 (0.10%) versus 109/93,395 (0.11%) in PHC-focused districts, respectively (OR: 2.92 [1.25-6.81; p-value = 0.013; p-value = 0.26 after correcting for over-dispersion). Interpretation Decentralising and strengthening childhood TB diagnosis at lower levels of care increases tuberculosis case detection but the difference was not statistically significant.
Plan de classement
Santé : généralités [050]
Description Géographique
CAMBODGE ; CAMEROUN ; COTE D'IVOIRE ; MOZAMBIQUE ; SIERRA LEONE ; OUGANDA
Localisation
Fonds IRD [F B010091271]
Identifiant IRD
fdi:010091271
