Sossou D., Ezinmegnon S., Agbota Gino, Gbedande K., Accrombessi M., Massougbodji A., d'Almeida M., Alao J. M., Dossou-Dagba I., Pachot A., Vachot L., Brengel-Pesce K., Cottrell Gilles, Yessoufou A., Briand Valérie, Tissieres P., Fievet Nadine. (2024). Regulatory T cell homing and activation is a signature of neonatal sepsis. Frontiers in Immunology, 15, p. 1420554 [17 p.]. ISSN 1664-3224.
Titre du document
Regulatory T cell homing and activation is a signature of neonatal sepsis
Année de publication
2024
Auteurs
Sossou D., Ezinmegnon S., Agbota Gino, Gbedande K., Accrombessi M., Massougbodji A., d'Almeida M., Alao J. M., Dossou-Dagba I., Pachot A., Vachot L., Brengel-Pesce K., Cottrell Gilles, Yessoufou A., Briand Valérie, Tissieres P., Fievet Nadine
Source
Frontiers in Immunology, 2024,
15, p. 1420554 [17 p.] ISSN 1664-3224
Regulatory T cells (Treg) play a prominent role in utero tolerating non-inherited maternal antigens and in regulating immune responses against pathogens at birth. This study investigates Treg immunity in newborns in West Africa, where sepsis remains a major public health problem. Treg phenotypes on neonates subgroups with early-onset sepsis (EOS), presumed sepsis, and healthy newborn with and without prenatal risk factors were evaluated. Treg phenotypes varied according to prenatal conditions, with increase in Treg frequency and Foxp3 expression in healthy newborns with prenatal risk factors compared to those with none risk. Compared to healthy newborns with prenatal risk factors, EOS neonates had a significantly reduced frequency of Treg and Foxp3 expression. In the Treg pool, higher frequency of activated Treg was observed in EOS neonates, suggesting an in-utero activation upstream of the sepsis onset. Their migration to the infection site may explain the reduced frequency of circulating Integrin alpha 4 beta 1+ Treg suggestive of homing to the endothelial tissue. EOS neonates show increases expression of CTLA-4, PD-1 and CD39 on Treg, which negatively regulate the activation of effector T cells (Teff) corroborating by the lower frequency of Teff in EOS neonates. The higher frequency of CD39+ Treg and the lower frequency of integrin alpha 4 beta 1+ Treg in EOS non-survivor suggests that Treg exhaustement and endothelial homing are associated with outcome severity. Neonates developing EOS are born with an altered Treg phenotypic profile. Treg expression of CTLA-4, PD-1, CD39, and integrin alpha 4 beta 1 cell markers can be considered as early warning or diagnostic markers of EOS.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
Localisation
Fonds IRD [F B010091155]
Identifiant IRD
fdi:010091155
