Orozco-Arias S., Lopez-Murillo L. H., Piña J. S., Valencia-Castrillon E., Tabares-Soto R., Castillo-Ossa L., Isaza G., Guyot Romain. (2023). Genomic object detection : an improved approach for transposable elements detection and classification using convolutional neural networks. Plos One, 18 (9), p. e0291925 [23 p.]. ISSN 1932-6203.
Titre du document
Genomic object detection : an improved approach for transposable elements detection and classification using convolutional neural networks
Année de publication
2023
Auteurs
Orozco-Arias S., Lopez-Murillo L. H., Piña J. S., Valencia-Castrillon E., Tabares-Soto R., Castillo-Ossa L., Isaza G., Guyot Romain
Source
Plos One, 2023,
18 (9), p. e0291925 [23 p.] ISSN 1932-6203
Analysis of eukaryotic genomes requires the detection and classification of transposable elements (TEs), a crucial but complex and time-consuming task. To improve the performance of tools that accomplish these tasks, Machine Learning approaches (ML) that leverage computer resources, such as GPUs (Graphical Processing Unit) and multiple CPU (Central Processing Unit) cores, have been adopted. However, until now, the use of ML techniques has mostly been limited to classification of TEs. Herein, a detection-classification strategy (named YORO) based on convolutional neural networks is adapted from computer vision (YOLO) to genomics. This approach enables the detection of genomic objects through the prediction of the position, length, and classification in large DNA sequences such as fully sequenced genomes. As a proof of concept, the internal protein-coding domains of LTR-retrotransposons are used to train the proposed neural network. Precision, recall, accuracy, F1-score, execution times and time ratios, as well as several graphical representations were used as metrics to measure performance. These promising results open the door for a new generation of Deep Learning tools for genomics. YORO architecture is available at https://github.com/simonorozcoarias/YORO.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
Localisation
Fonds IRD [F B010090309]
Identifiant IRD
fdi:010090309
