Salvadori N., Gauthier L., Guy M., Ngo-Giang-Huong Nicole, Khamduang W., Decker Luc, Achalapong J., Mary J.Y., Sirirungsi W., Pornprasert S., Arunothong S., Ongwandee S., Jourdain Gonzague. (2023). Hepatitis B prevalence and associated factors in adults presenting for infection screening in northern Thailand. Journal of Virus Eradication, 9 (4), 100356 [5 p.]. ISSN 2055-6659.
Titre du document
Hepatitis B prevalence and associated factors in adults presenting for infection screening in northern Thailand
Année de publication
2023
Auteurs
Salvadori N., Gauthier L., Guy M., Ngo-Giang-Huong Nicole, Khamduang W., Decker Luc, Achalapong J., Mary J.Y., Sirirungsi W., Pornprasert S., Arunothong S., Ongwandee S., Jourdain Gonzague
Source
Journal of Virus Eradication, 2023,
9 (4), 100356 [5 p.] ISSN 2055-6659
Background and aims : Hepatitis B is a leading cause of morbidity and mortality worldwide. In view of the World Health Organization 2030 targets, effective screening of chronic infection is crucial. We have assessed the prevalence and risk factors of hepatitis B surface antigen in adults presenting for screening. Methods : Free-of-charge and anonymous services for simultaneous hepatitis B, hepatitis C, human immunodeficiency virus and syphilis screening and counseling were provided in four facilities in northern Thailand. Analyses were performed separately in clients born before integration into the 1992 hepatitis B vaccine Thailand's Expanded Program on Immunization and in clients born afterwards. Results : Between October 2015 and August 2020, hepatitis B surface antigen prevalence was 7.2 % (185/2578) in clients born before 1992 (95 % confidence interval [CI] = 6.2%-8.2 %). In the multivariable analysis, characteristics independently associated with a higher risk of infection were being born male (adjusted odds ratio [aOR] = 1.49, 95 % CI = 1.10-2.01) and being part of a hill tribe (aOR = 1.65, 95 % CI = 1.01-2.70). Forty-two percent were unaware of their infection. In clients born in 1992 or afterwards, prevalence was 1.5 % (43/2933) (95 % CI = 1.1%-2.0 %) and characteristics independently associated with a higher risk were being born between 1992 and 1995 (aOR = 1.90, 95 % CI = 1.00-3.61), being born male (aOR = 2.60, 95 % CI = 1.34-5.07), being part of a hill tribe (aOR = 5.09, 95 % CI = 2.52-10.26) and having ever injected drugs (aOR = 4.33, 95 % CI = 1.23-15.24). Conclusions : Risk factor-based screening would miss many chronic hepatitis cases. Screening all adults once in their lifetime may be beneficial until the second generation of immunized infants have reached adult age.
Plan de classement
Maladies virales (sauf arbovirus) [052MALTRA01]
Localisation
Fonds IRD [F B010089133]
Identifiant IRD
fdi:010089133
