Publications des scientifiques de l'IRD

Rakotomalala F. A., Bouillin Julie, Randriarimanana S. D., Thaurignac G., Maharavo L., Raberahona M., Razafindrakoto L., Rasoanarivo J., Rakoto-Andrianarivelo M., Rakoto D. A. D., Babin F. X., Rasamoelina T., Delaporte E., Samison L. H., Peeters Martine, Nerrienet E., Ayouba Ahidjo. (2023). High seroprevalence of IgG antibodies to multiple arboviruses in people living with HIV (PLWHIV) in Madagascar. Viruses, 15 (11), p. 2258 [12 p.].

Titre du document
High seroprevalence of IgG antibodies to multiple arboviruses in people living with HIV (PLWHIV) in Madagascar
Année de publication
2023
Type de document
Article référencé dans le Web of Science WOS:001113954100001
Auteurs
Rakotomalala F. A., Bouillin Julie, Randriarimanana S. D., Thaurignac G., Maharavo L., Raberahona M., Razafindrakoto L., Rasoanarivo J., Rakoto-Andrianarivelo M., Rakoto D. A. D., Babin F. X., Rasamoelina T., Delaporte E., Samison L. H., Peeters Martine, Nerrienet E., Ayouba Ahidjo
Source
Viruses, 2023, 15 (11), p. 2258 [12 p.]
To estimate the prevalence of IgG antibodies against six arboviruses in people living with HIV-1 (PLWHIV) in Madagascar, we tested samples collected between January 2018 and June 2021. We used a Luminex-based serological assay to detect IgG antibodies against antigens from Dengue virus serotypes 1-4 (DENV1-4), Zika virus (ZIKV), West Nile virus (WNV), Usutu virus (USUV), Chikungunya virus (CHIKV), and O'nyong nyong virus (ONNV). Of the 1036 samples tested, IgG antibody prevalence was highest for ONNV (28.4%), CHIKV (26.7%), WNV-NS1 (27.1%), DENV1 (12.4%), USUV (9.9%), and DENV3 (8.9%). ZIKV (4.9%), DENV2 (4.6%), WNV-D3 (5.1%), and DENV4 (1.4%) were lower. These rates varied by province of origin, with the highest rates observed in Toamasina, on the eastern coast (50.5% and 56.8%, for CHIKV and ONNV, respectively). The seroprevalence increased with age for DENV1 and 3 (p = 0.006 and 0.038, respectively) and WNV DIII (p = 0.041). The prevalence of IgG antibodies against any given arborvirus varied over the year and significantly correlated with rainfalls in the different areas (r = 0.61, p = 0.036). Finally, we found a significant correlation between the seroprevalence of antibodies against CHIKV and ONNV and the HIV-1 RNA plasma viral load. Thus, PLWHIV in Madagascar are highly exposed to various arboviruses. Further studies are needed to explain some of our findings.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
MADAGASCAR
Localisation
Fonds IRD [F B010088704]
Identifiant IRD
fdi:010088704
Contact