Association between altered cognition and Loa loa microfilaremia : first evidence from a cross-sectional study in a rural area of the Republic of Congo

2023

Article référencé dans le Web of Science WOS:001016222900004

Checkouri T., Missamou F., Pion Sébastien, Bikita P., Hemilembolo M. C., Boussinesq Michel, Chesnais Cédric, Campillo Jérémy

PLoS Neglected Tropical Diseases, 2023, 17 (6), p. e0011430 [15 p.] ISSN 1935-2735

Author summaryIndividuals with high Loa loa blood microfilarial densities are at risk of developing a serious encephalopathy after administration of antiparasitic drugs. Apart from this major inconvenience, L. loa filariasis (loiasis) is considered a benign disease, with no effect on brain function. However, recent epidemiological data suggest an increased mortality and morbidity in L. loa infected individuals, underscoring the importance of studies on the possible neurological morbidity associated with loiasis. This cross-sectional study assessed cognition using MoCA tests (Montreal Cognitive assessments, a tool for early detection of mild cognitive impairment) and neurological ultrasound among 143 matched individuals with either no microfilaremia, low microfilaremia or high microfilaremia. People with high microfilaremia were more than twenty times more likely to have an altered cognition, compared to individuals with no microfilaremia. BackgroundIndividuals with high Loa loa microfilarial densities are at risk of developing severe encephalopathy after administration of antiparasitic drugs. Apart from this finding, loiasis is considered benign with no effect on brain function. However, recent epidemiological data suggest an increased mortality and morbidity in L. loa infected individuals, underscoring the importance of studies on the possible neurological morbidity associated with loiasis. MethodologyUsing MoCA tests and neurological ultrasounds, we conducted a cross-sectional study to assess cognitive alteration in a population living in a rural area endemic for loiasis in the Republic of Congo. Fifty individuals with high microfilarial densities (MFD) were matched on sex, age and residency with 50 individuals with low MFD and 50 amicrofilaremic subjects.Analyses focused on individuals with MoCA scores indicating an altered cognition (i.e. < 23/30) and on the total MoCA score according to Loa loa MFD, sociodemographic characteristics and neurological ultrasound results. Principal findingsMoCA scores were very low in the studied population (mean of 15.6/30). Individuals with more than 15,000 microfilariae per milliliter of blood (mean predicted score:14.0/30) are more than twenty times more likely to have an altered cognition, compared to individuals with no microfilaremia (mean predicted score: 16.3/30). Years of schooling were strongly associated with better MoCA results. Extracranial and intracranial atheroma were not associated with L. loa MFD. Conclusion/significanceLoaisis microfilaremia is probably involved in cognitive impairment, especially when the MFD are high. These results highlight the urgent need to better understand loaisis-induced morbidity. Further studies investigating neurological morbidity of loiasis are needed.

Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]

CONGO

Fonds IRD [F B010088243]

fdi:010088243