Sanders J. G., Sprockett D. D., Li Y. Y., Mjungu D., Lonsdorf E. V., Ndjango J. B. N., Georgiev A. V., Hart J. A., Sanz C. M., Morgan D. B., Peeters Martine, Hahn B. H., Moeller A. H. (2023). Widespread extinctions of co-diversified primate gut bacterial symbionts from humans. Nature Microbiology, 8, p. 1039-1050. ISSN 2058-5276.
Titre du document
Widespread extinctions of co-diversified primate gut bacterial symbionts from humans
Année de publication
2023
Auteurs
Sanders J. G., Sprockett D. D., Li Y. Y., Mjungu D., Lonsdorf E. V., Ndjango J. B. N., Georgiev A. V., Hart J. A., Sanz C. M., Morgan D. B., Peeters Martine, Hahn B. H., Moeller A. H.
Source
Nature Microbiology, 2023,
8, p. 1039-1050 ISSN 2058-5276
Humans and other primates harbour complex gut bacterial communities that influence health and disease, but the evolutionary histories of these symbioses remain unclear. This is partly due to limited information about the microbiota of ancestral primates. Here, using phylogenetic analyses of metagenome-assembled genomes (MAGs), we show that hundreds of gut bacterial clades diversified in parallel (that is, co-diversified) with primate species over millions of years, but that humans have experienced widespread losses of these ancestral symbionts. Analyses of 9,460 human and non-human primate MAGs, including newly generated MAGs from chimpanzees and bonobos, revealed significant co-diversification within ten gut bacterial phyla, including Firmicutes, Actinobacteriota and Bacteroidota. Strikingly, similar to 44% of the co-diversifying clades detected in African apes were absent from available metagenomic data from humans and similar to 54% were absent from industrialized human populations. In contrast, only similar to 3% of non-co-diversifying clades detected in African apes were absent from humans. Co-diversifying clades present in both humans and chimpanzees displayed consistent genomic signatures of natural selection between the two host species but differed in functional content from co-diversifying clades lost from humans, consistent with selection against certain functions. This study discovers host-species-specific bacterial symbionts that predate hominid diversification, many of which have undergone accelerated extinctions from human populations.
Plan de classement
Nutrition, alimentation [054]
;
Sciences du monde animal [080]
;
Biotechnologies [084]
Description Géographique
AFRIQUE ; MONDE
Localisation
Fonds IRD [F B010087754]
Identifiant IRD
fdi:010087754
