Garcia-Lopez R., Rivera-Gutierrez X., Rosales-Rivera M., Zarate S., Munoz-Medina J. E., Roche Benjamin, Herrera-Estrella A., Gomez-Gil B., Sanchez-Flores A., Taboada B., Arias C. F. (2023). SARS-CoV-2 BW lineage, a fast-growing Omicron variant from southeast Mexico bearing relevant escape mutations. Infection, [Early access], p. [7 p.]. ISSN 0300-8126.
Titre du document
SARS-CoV-2 BW lineage, a fast-growing Omicron variant from southeast Mexico bearing relevant escape mutations
Année de publication
2023
Auteurs
Garcia-Lopez R., Rivera-Gutierrez X., Rosales-Rivera M., Zarate S., Munoz-Medina J. E., Roche Benjamin, Herrera-Estrella A., Gomez-Gil B., Sanchez-Flores A., Taboada B., Arias C. F.
Source
Infection, 2023,
[Early access], p. [7 p.] ISSN 0300-8126
PurposeThe swift expansion of the BW.1 SARS-CoV-2 variant coincided with a rapid increase of COVID-19 cases occurring in Southeast Mexico in October, 2022, which marked the start of Mexico's sixth epidemiological wave. In Yucatan, up to 92% (58 of 73) of weekly sequenced genomes between epidemiological week 42 and 47 were identified as either BW.1 or its descendant, BW.1.1 in the region, during the last trimester of 2022. In the current study, a comprehensive genomic comparison was carried out to characterize the evolutionary history of the BW lineage, identifying its origins and its most important mutations.MethodsAn alignment of all the genomes of the BW lineage and its parental BA.5.6.2 variant was carried out to identify their mutations. A phylogenetic and ancestral sequence reconstruction analysis with geographical inference, as well as a longitudinal analysis of point mutations, were performed to trace back their origin and contrast them with key RBD mutations in variant BQ.1, one of the fastest-growing lineages to date.ResultsOur ancestral reconstruction analysis portrayed Mexico as the most probable origin of the BW.1 and BW.1.1 variants. Two synonymous substitutions, T7666C and C14599T, support their Mexican origin, whereas other two mutations are specific to BW.1: S:N460K and ORF1a:V627I. Two additional substitutions and a deletion are found in its descending subvariant, BW.1.1. Mutations found in the receptor binding domain, S:K444T, S:L452R, S:N460K, and S:F486V in BW.1 have been reported to be relevant for immune escape and are also key mutations in the BQ.1 lineage.ConclusionsBW.1 appears to have arisen in the Yucatan Peninsula in Southeast Mexico sometime around July 2022 during the fifth COVID-19 wave. Its rapid growth may be in part explained by the relevant escape mutations also found in BQ.1.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
MEXIQUE
Localisation
Fonds IRD [F B010087687]
Identifiant IRD
fdi:010087687
