Publications des scientifiques de l'IRD

Receveur J. P., Bauer A., Pechal J. L., Picq S., Dogbe M., Jordan H. R., Rakestraw A. W., Fast K., Sandel M., Chevillon C., Guégan Jean-François, Wallace J. R., Benbow M. E. (2022). A need for null models in understanding disease transmission : the example of Mycobacterium ulcerans (Buruli ulcer disease). FEMS Microbiology Reviews, 46 (1), fuab045 [22 p.]. ISSN 0168-6445.

Titre du document
A need for null models in understanding disease transmission : the example of Mycobacterium ulcerans (Buruli ulcer disease)
Année de publication
2022
Type de document
Article référencé dans le Web of Science WOS:000753584800008
Auteurs
Receveur J. P., Bauer A., Pechal J. L., Picq S., Dogbe M., Jordan H. R., Rakestraw A. W., Fast K., Sandel M., Chevillon C., Guégan Jean-François, Wallace J. R., Benbow M. E.
Source
FEMS Microbiology Reviews, 2022, 46 (1), fuab045 [22 p.] ISSN 0168-6445
Understanding the interactions of ecosystems, humans and pathogens is important for disease risk estimation. This is particularly true for neglected and newly emerging diseases where modes and efficiencies of transmission leading to epidemics are not well understood. Using a model for other emerging diseases, the neglected tropical skin disease Buruli ulcer (BU), we systematically review the literature on transmission of the etiologic agent, Mycobacterium ulcerans (MU), within a One Health/EcoHealth framework and against Hill's nine criteria and Koch's postulates for making strong inference in disease systems. Using this strong inference approach, we advocate a null hypothesis for MU transmission and other understudied disease systems. The null should be tested against alternative vector or host roles in pathogen transmission to better inform disease management. We propose a re-evaluation of what is necessary to identify and confirm hosts, reservoirs and vectors associated with environmental pathogen replication, dispersal and transmission; critically review alternative environmental sources of MU that may be important for transmission, including invertebrate and vertebrate species, plants and biofilms on aquatic substrates; and conclude with placing BU within the context of other neglected and emerging infectious diseases with intricate ecological relationships that lead to disease in humans, wildlife and domestic animals. This review uses a case study example to demonstrate the importance of identifying unknown transmission pathways for neglected and emerging diseases, supporting broader One Health calls for elucidating the ecology and evolution of emerging pathogens predicted to occur with local and global changes.
Plan de classement
Sciences du milieu [021] ; Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Biotechnologies [084]
Localisation
Fonds IRD [F B010084310]
Identifiant IRD
fdi:010084310
Contact