Publications des scientifiques de l'IRD

Chene A., Briand Valérie, Ibitokou S., Dechavanne S., Massougbodji A., Deloron Philippe, Luty Adrian, Gamain B., Fievet Nadine. (2014). Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection. Infection and Immunity, 82 (9), p. 3783-3789. ISSN 0019-9567.

Titre du document
Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection
Année de publication
2014
Type de document
Article référencé dans le Web of Science WOS:000341932700026
Auteurs
Chene A., Briand Valérie, Ibitokou S., Dechavanne S., Massougbodji A., Deloron Philippe, Luty Adrian, Gamain B., Fievet Nadine
Source
Infection and Immunity, 2014, 82 (9), p. 3783-3789 ISSN 0019-9567
Pregnancy-associated malaria (PAM) can lead to severe complications for both mother and baby. Certain placental cytokine/chemokine profiles have been shown to reflect poor pregnancy outcomes, including maternal anemia and low birth weight. In intervillous plasma samples from 400 Beninese women living in an area where Plasmodium falciparum is endemic, we quantified 16 cytokines/chemokines. We assessed their profiles in groups with PAM, with maternal anemia, with preterm births, or with a low birth weight for gestational age. Repeated ultrasound measurements ensured that prematurity and low birth weight were highly accurate. Preliminary analyses revealed trends for lower cytokine/chemokine concentrations in placental plasma associated both with babies with low birth weight for gestational age and with P. falciparum infection during pregnancy, while, as a function of the latter, the concentration of gamma interferon (IFN-gamma)-inducible protein 10 (IP-10) was higher. Multivariate analyses showed that (i) higher placental plasma interleukin-10 (IL-10) levels were associated with P. falciparum infections and (ii) independently of P. falciparum infections, lower concentrations of both IFN-gamma and IL-5 were associated with low birth weight for gestational age. Our data further strengthen the idea that IL-10 and IP-10 could be useful diagnostic markers of P. falciparum infection during pregnancy. The concentrations of cytokines/chemokines in placental plasma may represent previously unrecognized markers of poor fetal growth.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010080761]
Identifiant IRD
fdi:010080761
Contact