Publications des scientifiques de l'IRD

Calvez E., Pommelet V., Somlor S., Pompon Julien, Viengphouthong S., Bounmany P., Chindavong T. A., Xaybounsou T., Prasayasith P., Keosenhom S., Brey P. T., Telle O., Choisy Marc, Marcombe S., Grandadam M. (2020). Trends of the dengue serotype-4 circulation with epidemiological, phylogenetic, and entomological insights in Lao PDR between 2015 and 2019. Pathogens, 9 (9), 728 [17 p.].

Titre du document
Trends of the dengue serotype-4 circulation with epidemiological, phylogenetic, and entomological insights in Lao PDR between 2015 and 2019
Année de publication
2020
Type de document
Article référencé dans le Web of Science WOS:000581988700001
Auteurs
Calvez E., Pommelet V., Somlor S., Pompon Julien, Viengphouthong S., Bounmany P., Chindavong T. A., Xaybounsou T., Prasayasith P., Keosenhom S., Brey P. T., Telle O., Choisy Marc, Marcombe S., Grandadam M.
Source
Pathogens, 2020, 9 (9), 728 [17 p.]
Dengue outbreaks have regularly been recorded in Lao People's Democratic Republic (PDR) since the first detection of the disease in 1979. In 2012, an integrated arbovirus surveillance network was set up in Lao PDR and an entomological surveillance has been implemented since 2016 in Vientiane Capital. Here, we report a study combining epidemiological, phylogenetic, and entomological analyzes during the largest DENV-4 epidemic ever recorded in Lao PDR (2015-2019). Strikingly, from 2015 to 2019, we reported the DENV-4 emergence and spread at the country level after two large epidemics predominated by DENV-3 and DENV-1, respectively, in 2012-2013 and 2015. Our data revealed a significant difference in the median age of the patient infected by DENV-4 compared to the other serotypes. Phylogenetic analysis demonstrated the circulation of DENV-4 Genotype I at the country level since at least 2013. The entomological surveillance showed a predominance of Aedes aegypti compared to Aedes albopictus and high abundance of these vectors in dry and rainy seasons between 2016 and 2019, in Vientiane Capital. Overall, these results emphasized the importance of an integrated approach to evaluate factors, which could impact the circulation and the epidemiological profile of dengue viruses, especially in endemic countries like Lao PDR.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
LAOS
Localisation
Fonds IRD [F B010079888]
Identifiant IRD
fdi:010079888
Contact