Horizon / Plein textes La base de ressources documentaires de l'IRD



Publications des scientifiques de l'IRD

Boëte Christophe, Seston Morgan, Legros M. (2019). Strategies of host resistance to pathogens in spatially structured populations : an agent-based evaluation. Theoretical Population Biology, 130, 170-181. ISSN 0040-5809

Accès réservé (Intranet IRD) Demander le PDF

Lien direct chez l'éditeur doi:10.1016/j.tpb.2019.07.014

Strategies of host resistance to pathogens in spatially structured populations : an agent-based evaluation
Année de publication2019
Type de documentArticle référencé dans le Web of Science WOS:000501405700012
AuteursBoëte Christophe, Seston Morgan, Legros M.
SourceTheoretical Population Biology, 2019, 130, p. 170-181. ISSN 0040-5809
RésuméThere is growing theoretical evidence that spatial structure can affect the ecological and evolutionary outcomes of host-parasite interactions. Locally restricted interactions have been shown in particular to affect host resistance and tolerance. In this study we investigate the evolution of several types of host disease resistance strategies, alone or in combination, in spatially structured populations. We construct a spatially explicit, individual-based stochastic model where hosts and parasites interact with each other in a spatial lattice, and interactions are restricted to a given neighbourhood of varying size. We investigate several host resistance strategies, including constitutive (expressed in all resistant hosts), induced (expressed only upon infection), and combinations thereof. We show that a costly constitutive resistance cannot reach fixation, whereas an inducible resistance strategy may become fixed in the population if the cost remains low, particularly if it impacts host recovery. We also demonstrate that mixed strategies can be maintained in the host population, and that a higher investment in a recovery-boosting inducible resistance allows for a higher investment in a constitutive response. Our simulations reveal that the spatial structure of the population impacts the selection for resistance in a complex fashion. While single strategies of resistance are generally favoured in less structured populations, mixed strategies can sometimes prevail only in highly structured environments, e.g. when combining constitutive and transmission-blocking induced responses Overall these results shed new light on the dynamics of disease resistance in a spatially-structured host-pathogen system, and advance our theoretical understanding of the evolutionary dynamics of disease resistance, a necessary step to elaborate more efficient and sustainable strategies for disease management.
Plan de classementSciences fondamentales / Techniques d'analyse et de recherche [020] ; Informatique [122]
LocalisationFonds IRD [F B010077448]
Identifiant IRDfdi:010077448
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010077448

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL

Accès aux documents originaux :

Le FDI est labellisé CollEx

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation


Montpellier (centre IRD)

Montpellier (MSE)









La Paz