Roche Benjamin, Martinez P. (2019). Separating the local and malignant dimensions of cancer adaptation. Cancer Informatics, 18, p. art. 1176935119872954 [3 p.].
Titre du document
Separating the local and malignant dimensions of cancer adaptation
Cancer Informatics, 2019,
18, p. art. 1176935119872954 [3 p.]
The repeatability observed across cancers arising in the same tissue can help understand the evolutionary process of tumour initiation. We recently developed a framework to quantify the local malignant adaptation of genetic clones in tissue-specific environments, In this Commentary, we argue that such a 1-dimensional model can be improved by separating its 2 components to obtain a dual scale: local adaptation, dictating proliferation rates in the local environment, and malignant adaptation, influencing the likelihood that a clone becomes cancerous and invasive. Such a change could strengthen our understanding of the population dynamics underlying cancer initiation and assess different evolutionary scenarios.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
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Santé : généralités [050]
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Informatique [122]
