Publications des scientifiques de l'IRD

Caron A., Bourgarel M., Cappelle J., Liégeois Florian, De Nys H. M., Roger F. (2018). Ebola virus maintenance : if not (only) bats, what else ?. Viruses-Basel, 10 (10), p. art. 549 [13 p.]. ISSN 1999-4915.

Titre du document
Ebola virus maintenance : if not (only) bats, what else ?
Année de publication
Type de document
Article référencé dans le Web of Science WOS:000448821200037
Caron A., Bourgarel M., Cappelle J., Liégeois Florian, De Nys H. M., Roger F.
Viruses-Basel, 2018, 10 (10), p. art. 549 [13 p.] ISSN 1999-4915
The maintenance mechanisms of ebolaviruses in African forest ecosystems are still unknown, but indirect evidences point at the involvement of some bat species. Despite intense research, the main bat-maintenance hypothesis has not been confirmed yet. The alternative hypotheses of a non-bat maintenance host or a maintenance community including, or not, several bat and other species, deserves more investigation. However, African forest ecosystems host a large biodiversity and abound in potential maintenance hosts. How does one puzzle out? Since recent studies have revealed that several bat species have been exposed to ebolaviruses, the common denominator to these hypotheses is that within the epidemiological cycle, some bats species must be exposed to the viruses and infected by these potential alternative hosts. Under this constraint, and given the peculiar ecology of bats (roosting behaviour, habitat utilisation, and flight mode), we review the hosts and transmission pathways that can lead to bat exposure and infection to ebolaviruses. In contrast to the capacity of bats to transmit ebolaviruses and other pathogens to many hosts, our results indicate that only a limited number of hosts and pathways can lead to the transmission of ebolaviruses to bats, and that the alternative maintenance host, if it exists, must be amongst them. A list of these pathways is provided, along with protocols to prioritise and investigate these alternative hypotheses. In conclusion, taking into account the ecology of bats and their known involvement in ebolaviruses ecology drastically reduces the list of potential alternative maintenance hosts for ebolaviruses. Understanding the natural history of ebolaviruses is a health priority, and investigating these alternative hypotheses could complete the current effort focused on the role of bats.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde animal [080]
Description Géographique
Fonds IRD [F B010074366]
Identifiant IRD