Publications des scientifiques de l'IRD

Konou A. A., Vidal Nicole, Salou M., Anato S., Singo-Tokofai A., Ekouevi D. K., Pitche P., Prince-David M., Delaporte Eric, Peeters Martine, Dagnra A. Y. (2016). Genetic diversity and transmission networks of HIV-1 strains among men having sex with men (MSM) in Lome, Togo. Infection Genetics and Evolution, 46, p. 279-285. ISSN 1567-1348.

Titre du document
Genetic diversity and transmission networks of HIV-1 strains among men having sex with men (MSM) in Lome, Togo
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000390456000037
Auteurs
Konou A. A., Vidal Nicole, Salou M., Anato S., Singo-Tokofai A., Ekouevi D. K., Pitche P., Prince-David M., Delaporte Eric, Peeters Martine, Dagnra A. Y.
Source
Infection Genetics and Evolution, 2016, 46, p. 279-285 ISSN 1567-1348
Understanding the HIV epidemic in key populations is important. Today only scarce information is available on HIV-1 strains that circulate in men having sex with men (MSM) in sub-Saharan Africa. Here, we studied for the first time the genetic diversity of HIV-1 strains circulating in the MSM population in Lome, the capital city from Togo. The overall subtype/CRF distribution in pol (protease and/or partial reverse transcriptase (RT)) among the 79 HIV-1 strains from MSM was as follows: CRF02_AG (72%, n = 57), subtype G (2.5%, n = 2), subsubtype A3 (1.3%, n = 1), and unique recombinant forms (URF) (24%, n = 19). Among the 19 URFs four different mosaic structures were observed, annotated as URF1 to URF4. Fifteen sequences (URF1) had the same mosaic structure in pol (G/CRF02_AG) and could represent a new circulating recombinant form (CRF). Phylogenetic analysis of the RT sequences showed that there were several introductions of CRF02_AG strains in the MSM population, however half of the CRF02_AG and all URF1 strains formed a separate, well-supported cluster suggesting one major introduction of CRF02_AG in the MSM population followed by efficient transmission and emergence of a possible new CRF. At least 40% of the strains fell into recent transmission chains involving two to seven MSM. Comparison with N950 HIV-1 sequences from previous studies in Togo showed intermixing of the HIV-1 epidemics between MSM and the general population. Moreover, an HIV-1 strain from a recently HIV-1 infected male patient from Germany, fell within a cluster of HIV-1 strains from MSM from Togo, illustrating recent exchange between MSM from Africa and people from other geographic regions. With growing evidence of the importance of MSM in the dynamic of the HIV epidemic in Africa there is an urgent need for appropriate interventions to limit HIV transmission in this population group.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
TOGO ; LOME
Localisation
Fonds IRD [F B010068808]
Identifiant IRD
fdi:010068808
Contact