Sabbagh A., Courtin David, Milet Jacqueline, Massaro J. D., Castelli E. C., Migot Nabias Florence, Favier B., Rouas-Freiss N., Moreau P., Garcia André, Donadi E. A. (2013). Association of HLA-G 3 ' untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens : preliminary results. Tissue Antigens, 82 (1), p. 53-58. ISSN 0001-2815.
Titre du document
Association of HLA-G 3 ' untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens : preliminary results
Sabbagh A., Courtin David, Milet Jacqueline, Massaro J. D., Castelli E. C., Migot Nabias Florence, Favier B., Rouas-Freiss N., Moreau P., Garcia André, Donadi E. A.
Source
Tissue Antigens, 2013,
82 (1), p. 53-58 ISSN 0001-2815
Host and Plasmodium interactions result in highly variable clinical phenotypes, partly explained by the nature and level of anti-malarial antibody response. Human leukocyte antigen (HLA)-G can create a tolerogenic environment, allowing parasites to escape from anti-malarial immunity. We performed a family-based association study encompassing 483 Sereer individuals (261 children and their parents), and reported two independent signals at the HLA-G 3' untranslated region associated with antibody response to specific Plasmodium falciparum blood stage antigens, previously associated with malaria protection: (i) +3010G together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with IgG3 against MSP2. While these results require further investigation, they suggest for the first time a role of HLA-G in the regulation of humoral immune response in malaria.
