Djoko C. F., Wolfe N. D., Vidal Nicole, Tamoufe U., Montavon Céline, LeBreton M., Pike B. L., Fair J., Mbacham W. F., Benito A., Rimoin A. W., Saylors K., Mpoudi Ngole E., Grillo M. P., Peeters Martine. (2010). HIV type 1 pol gene diversity and genotypic antiretroviral drug resistance mutations in Malabo, Equatorial Guinea. Aids Research and Human Retroviruses, 26 (9), p. 1027-1031. ISSN 0889-2229.
Titre du document
HIV type 1 pol gene diversity and genotypic antiretroviral drug resistance mutations in Malabo, Equatorial Guinea
Année de publication
2010
Auteurs
Djoko C. F., Wolfe N. D., Vidal Nicole, Tamoufe U., Montavon Céline, LeBreton M., Pike B. L., Fair J., Mbacham W. F., Benito A., Rimoin A. W., Saylors K., Mpoudi Ngole E., Grillo M. P., Peeters Martine
Source
Aids Research and Human Retroviruses, 2010,
26 (9), p. 1027-1031 ISSN 0889-2229
In this study, HIV strains circulating among military personnel were characterized, in Malabo, the capital city of Equatorial Guinea. One sample was found to be HIV-2 group A while a high degree of genetic diversity was recorded in the pol region of 41 HIV-1-positive samples. CRF02_AG accounted for 53.7% of the strains, and 11 different variants were obtained in the remaining 19 samples: subtype G (n=3), A3 (n=2), C (n=2), CRF26_A5U (n=2), F2 (n=1), CRF06 (n=1), CRF09 (n=1), CRF11 (n=1), CRF22 (n=1), and divergent subtype A (n=1) and F (n=1). One strain could not be classified and three were unique recombinants. Analysis of antiretroviral drug resistance mutations revealed two patients each harboring one major mutation, M46I in protease and D67N in reverse transcriptase sequences, respectively. The high genetic diversity and emerging ARV resistance mutations call for frequent surveys and appropriate monitoring of ARV considering the increasing access to ARV in the country.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010049049]
Identifiant IRD
fdi:010049049
