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Ndounga M., Mayengue P. I., Tahar Rachida, Casimiro P. N., Maya D. W. M., Miakassissa Mpassi V., Malonga D. A., Nsonde Ntandou F., Mallanda G., Ringwald Pascal, Basco Leonardo, Ntoumi F. (2007). Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo). Acta Tropica, 103 (3), 163-171. ISSN 0001-706X.

Titre du document
Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo)
Année de publication
2007
Type de document
Article référencé dans le Web of Science WOS:000249773200002
Auteurs
Ndounga M., Mayengue P. I., Tahar Rachida, Casimiro P. N., Maya D. W. M., Miakassissa Mpassi V., Malonga D. A., Nsonde Ntandou F., Mallanda G., Ringwald Pascal, Basco Leonardo, Ntoumi F.
Source
Acta Tropica, 2007, 103 (3), 163-171 ISSN 0001-706X
Congo-Brazzaville has recently adopted artesunate-amodiaquine as the first-line antimalarial drug to replace chloroquine. Before the implementation of this new strategy, we conducted several clinical studies to assess the therapeutic efficacy of former, classical first-line antimalarial drugs in the city of Brazzaville, in which reside about 30% of the Congolese population. From 2003 to 2005, non-randomised trials were conducted to evaluate the efficacy of sulfadoxine-pyrimethamine (SP) (n = 97 patients), amodiaquine (AQ) (n = 62 patients), and the combination of sulfadoxine-pyrimethamine-amodiaquine (n = 54 patients) in children aged between 6 months and 5 years with uncomplicated malaria using the 2003 WHO guidelines during the 28-day follow-up period. After excluding new infections by PCR, the proportion of treatment failure on day 28 was 30.2% (95% confidence interval, 19.2-43.0%) for sulfadoxine-pyrimethamine, 34.8% (95% confidence interval, 21.4-50.2%) for amodiaquine, and 14.2% (95% confidence interval, 5.9-27.2%) for sulfadoxine-pyrimethamine + amodiaquine combination. Treatment with sulfadoxine-pyrimethamine was associated with an increase of gametocyte charge. These results suggest that neither sulfadoxine-pyrimethamine nor amodiaquine is efficacious as monotherapy and that their combination may not remain effective in the coming years. Based on our results, the implementation of artemisinin-based combination therapy appears to be urgent in the country.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CONGO
Localisation
Fonds IRD [F B010040790]
Identifiant IRD
fdi:010040790
Contact