Montavon Céline, Toure-Kane C., Liégeois Florian, Mpoudi Ngolé E., Bourgeois Anke, Vergne Laurence, Perret J.L., Boumah A., Saman E., Mboup S., Delaporte Eric, Peeters Martine. (2000). Most env and gag subtype A HIV-1 viruses circulating in West and West Central Africa are similar to the prototype AG recombinant virus IBNG. Journal of Acquired Immune Deficiency Syndromes, 23 (5), p. 363-374. ISSN 1525-4135.
Titre du document
Most env and gag subtype A HIV-1 viruses circulating in West and West Central Africa are similar to the prototype AG recombinant virus IBNG
Année de publication
2000
Auteurs
Montavon Céline, Toure-Kane C., Liégeois Florian, Mpoudi Ngolé E., Bourgeois Anke, Vergne Laurence, Perret J.L., Boumah A., Saman E., Mboup S., Delaporte Eric, Peeters Martine
Source
Journal of Acquired Immune Deficiency Syndromes, 2000,
23 (5), p. 363-374 ISSN 1525-4135
The genetic subtype was identified in gag and env of 219 HIV-1-positive samples collected in different African countries, 44 from Senegal, 55 from Cameroon, 82 from Gabon, and 38 from Djibouti. In total, 20 (9.1%) samples had discordant subtypes between gag and env, 6 of 44 (13.9%) in Senegal, 4 of 55 (7.2%) in Cameroon, 1 of 38 (2.6%) in Djibouti, and 10 of 82 (12.1%) in Gabon. Subtypes A and G were predominantly involved in the recombination events. Phylogenetic tree analysis of gag showed that an important number of the A sequences form a distinct subcluster with the AG-IBNG prototype strain (a complex A/G mosaic virus) : 27 of 32 (84.3%) in Senegal, 12 of 17 (70.6%) in Nigeria, 24 of 39 (61.5%) in Cameroon, and 38 of 70 (54.3%) in Gabon. Full-length genome analysis of 3 and additional sequences in pol for 10 such strains confirmed that they have a similar complex A/G mosaic genomic structure. These data suggest that in West Africa, most probably between 60% and 84% of the subtype A viruses are recombinant AG-IBNG viruses. This finding has potential implications on future vaccine, diagnostic, and treatment strategies. The actual and future role of these viruses in the global pandemic must be monitored in all new molecular epidemiologic studies, a discrimination between subtype A and AG-IBNG-like viruses is necessary. (Résumé d'auteur)
Plan de classement
Maladies sexuellement transmissibles [052MALTRA03]
Descripteurs
SIDA ; VIRUS ; PHYLOGENIE ; STRUCTURE GENETIQUE ; GENOME ; ANALYSE GENETIQUE ; GENE ENV ; GENE GAG ; RECOMBINAISON ; VIRUS AB IBNG ; GENE POL
Description Géographique
AFRIQUE ; SENEGAL ; CAMEROUN ; GABON ; DJIBOUTI ; NIGERIA
Localisation
Fonds IRD [F B010022766] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010022766
