Migot Nabias F., Luty A.J.F., Ringwald Pascal, Vaillant M., Dubois B., Renaut A., Mayombo J., Minh T.N., Fievet Nadine, Mbessi J.R., Millet P., Deloron P. (1999). Immune responses against Plasmodium falciparum asexual blood-stage antigens and disease susceptibility in Gabonese and Cameroonian children. American Journal of Tropical Medicine and Hygiene, 61 (3), p. 488-494. ISSN 0002-9637.
Titre du document
Immune responses against Plasmodium falciparum asexual blood-stage antigens and disease susceptibility in Gabonese and Cameroonian children
Année de publication
1999
Auteurs
Migot Nabias F., Luty A.J.F., Ringwald Pascal, Vaillant M., Dubois B., Renaut A., Mayombo J., Minh T.N., Fievet Nadine, Mbessi J.R., Millet P., Deloron P.
Source
American Journal of Tropical Medicine and Hygiene, 1999,
61 (3), p. 488-494 ISSN 0002-9637
The frequency and level of cellular and humoral responses to seven synthetic peptides from asexual blood stages of Plasmodium falciparum were measured in two cohorts of children living in areas highly endemic for malaria in Gabon and Cameroon. A prospective longitudinal study was conducted for one year in these sites to examine the relationship between specific in vitro immune responses (merozoite surface antigen-1 (MSA-1) and MSA-2 peptides) as well as to elevated antibody levels (schizont extract, MSA-2, and rhoptry-associated protein1 (RAP-1) peptides) in the village of Dienga, Gabon. Higher response rates of interferon-gamma but lower response rates of tumor necrosis factor-alpha to four and six peptides, respectively, were observed in Dienga than in Pouma that were independent of the older age of the Gabonese children. Age accounted only for the higher prevalence rate in Dienga of the antibody responders to the peptide from Pf155/ring-infected erythrocyte surface antigen (RESA). Our results support the inclusion of epitopes from MSA-1,MSA-2, RAP-1, and Pf155/RESA antigens in a subunit vaccine against malaria, but show that a longitudinal clinical, parasitologic, and immunologic study conducted according to identical criteria in two separate areas may lead to contrasting observations, demonstrating the geographic limitation of the interpretation of such results. (Résumé d'auteur)
Plan de classement
Lutte [052ANOPAL04]
Descripteurs
PALUDISME ; IMMUNITE ; VACCINATION ; ANTIGENE ; ENFANT D'AGE SCOLAIRE ; ANALYSE DE COHORTES ; ETUDE COMPARATIVE ; MSA.MEROZOITE SURFACE ANTIGEN ; MSA-1 ; MSA-2 ; RAP.RHOPTRY-ASSOCIATED PROTEIN ; RAP-1 ; PF155/RESA
Description Géographique
GABON ; CAMEROUN
Localisation
Fonds IRD [F B010019298] ;
Dakar
;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010019298
