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Colson P., Fournous G., Diene S. M., Raoult Didier. (2013). Codon usage, amino acid usage, transfer RNA and amino-acyl-tRNA synthetases in mimiviruses. Intervirology, 56 (6), 364-375. ISSN 0300-5526

Lien direct chez l'éditeur doi:10.1159/000354557

Codon usage, amino acid usage, transfer RNA and amino-acyl-tRNA synthetases in mimiviruses
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000325983600004
AuteursColson P., Fournous G., Diene S. M., Raoult Didier.
SourceIntervirology, 2013, 56 (6), p. 364-375. ISSN 0300-5526
RésuméMimiviruses are giant viruses that infect phagocytic protists, including Acanthamoebae spp., which were discovered during the past decade. They are the current record holder among viruses for their large particle and genome sizes. One group is composed of three lineages, referred to as A, B and C, which include the vast majority of the Mimiviridae members. Cafeteria roenbergensis virus represents a second group, though the Mimiviridae family is still expanding. We analyzed the codon and amino acid usages in mimiviruses, as well as both the transfer RNA (tRNA) and amino acyl-tRNA synthetases. We confirmed that the codon and amino acid usages of these giant viruses are highly dissimilar to those in their amoebal host Acanthamoeba castellanii and are instead correlated with the high adenine and thymine (AT) content of Mimivirus genomes. We further describe that the set of tRNAs and amino acyl-tRNA synthetases in mimiviruses is globally not adapted to the codon and amino acid usages of these viruses. Notwithstanding, Leu(TAA)tRNA, present in several Mimivirus genomes and in multiple copies in some viral genomes, may complement the amoebal tRNA pool and may contribute to accommodate the viral AT-rich codons. In addition, we found that the genes most highly expressed at the beginning of the Mimivirus replicative cycle have a nucleotide content more adapted to the codon usage in A. castellanii.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Sciences fondamentales / Techniques d'analyse et de recherche [020]
LocalisationFonds IRD
Identifiant IRDPAR00011189
Lien permanenthttp://www.documentation.ird.fr/hor/PAR00011189

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