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Boushab B. M., Salem M. S. O. A., Boukhary A. O. M. S., Parola P., Basco Leonardo. (2021). Clinical features and mortality associated with severe malaria in adults in Southern Mauritania. Tropical Medicine and Infectious Disease, 6 (1), p. 1 [10 p.].

Titre du document
Clinical features and mortality associated with severe malaria in adults in Southern Mauritania
Année de publication
2021
Type de document
Article référencé dans le Web of Science WOS:000633066100001
Auteurs
Boushab B. M., Salem M. S. O. A., Boukhary A. O. M. S., Parola P., Basco Leonardo
Source
Tropical Medicine and Infectious Disease, 2021, 6 (1), p. 1 [10 p.]
Severe malaria in adults is not well-studied in Sahelian Africa. Clinical features and mortality associated with severe Plasmodium falciparum malaria in adult patients hospitalized in Kiffa, southern Mauritania, were analysed. Patients over 15 years old admitted for severe malaria between August 2016 and December 2019 were included in the present retrospective study. The World Health Organization (WHO) criteria were used to define severe malaria. The presenting clinical characteristics and outcome were compared. Of 4266 patients hospitalized during the study period, 573 (13.4%) had a positive rapid diagnostic test for malaria, and 99 (17.3%; mean age, 37.5 years; range 15-79 years; sex-ratio M/F, 2.1) satisfied the criteria for severe malaria. On admission, the following signs and symptoms were observed in more than one-fourth of the patients: fever (98%), impairment of consciousness (81.8%), multiple convulsions (70.7%), cardiovascular collapse (61.6%), respiratory distress (43.4%), severe anaemia <= 80 g/L (36.4%), haemoglobinuria (27.3%), and renal failure (25.3%). Patients were treated with parenteral quinine or artemether. Fourteen (14.1%) patients died. Multiple convulsions, respiratory distress, severe anaemia, haemoglobinuria, acute renal failure, jaundice, and abnormal bleeding occurred more frequently (p < 0.05) in deceased patients. Mortality due to severe falciparum malaria is high among adults in southern Mauritania. An adoption of the WHO-recommended first-line treatment for severe malaria, such as parenteral artesunate, is required to lower the mortality rate associated with severe malaria.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
MAURITANIE ; ZONE SAHELIENNE
Localisation
Fonds IRD [F B010081148]
Identifiant IRD
fdi:010081148
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