@article{fdi:010081148,
  title = {{C}linical features and mortality associated with severe malaria in adults in {S}outhern {M}auritania},
  author = {{B}oushab, {B}. {M}. and {S}alem, {M}. {S}. {O}. {A}. and {B}oukhary, {A}. {O}. {M}. {S}. and {P}arola, {P}. and {B}asco, {L}eonardo},
  editor = {},
  language = {{ENG}},
  abstract = {{S}evere malaria in adults is not well-studied in {S}ahelian {A}frica. {C}linical features and mortality associated with severe {P}lasmodium falciparum malaria in adult patients hospitalized in {K}iffa, southern {M}auritania, were analysed. {P}atients over 15 years old admitted for severe malaria between {A}ugust 2016 and {D}ecember 2019 were included in the present retrospective study. {T}he {W}orld {H}ealth {O}rganization ({WHO}) criteria were used to define severe malaria. {T}he presenting clinical characteristics and outcome were compared. {O}f 4266 patients hospitalized during the study period, 573 (13.4%) had a positive rapid diagnostic test for malaria, and 99 (17.3%; mean age, 37.5 years; range 15-79 years; sex-ratio {M}/{F}, 2.1) satisfied the criteria for severe malaria. {O}n admission, the following signs and symptoms were observed in more than one-fourth of the patients: fever (98%), impairment of consciousness (81.8%), multiple convulsions (70.7%), cardiovascular collapse (61.6%), respiratory distress (43.4%), severe anaemia <= 80 g/{L} (36.4%), haemoglobinuria (27.3%), and renal failure (25.3%). {P}atients were treated with parenteral quinine or artemether. {F}ourteen (14.1%) patients died. {M}ultiple convulsions, respiratory distress, severe anaemia, haemoglobinuria, acute renal failure, jaundice, and abnormal bleeding occurred more frequently (p < 0.05) in deceased patients. {M}ortality due to severe falciparum malaria is high among adults in southern {M}auritania. {A}n adoption of the {WHO}-recommended first-line treatment for severe malaria, such as parenteral artesunate, is required to lower the mortality rate associated with severe malaria.},
  keywords = {artesunate ; drug resistance ; malaria ; quinine ; rapid diagnostic test ; {P}lasmodium falciparum ; {S}ahel ; {MAURITANIE} ; {ZONE} {SAHELIENNE}},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nfectious {D}isease},
  volume = {6},
  numero = {1},
  pages = {1 [10 p.]},
  year = {2021},
  DOI = {10.3390/tropicalmed6010001},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081148},
}