Publications des scientifiques de l'IRD

Bompard Anaïs, Da D. F., Yerbanga S. R., Morlais Isabelle, Awono-Ambene P. H., Dabire R. K., Ouedraogo J. B., Lefèvre Thierry, Churcher T. S., Cohuet Anna. (2020). High Plasmodium infection intensity in naturally infected malaria vectors in Africa. International Journal for Parasitology, 50 (12), p. 985-996. ISSN 0020-7519.

Titre du document
High Plasmodium infection intensity in naturally infected malaria vectors in Africa
Année de publication
2020
Type de document
Article référencé dans le Web of Science WOS:000582319000005
Auteurs
Bompard Anaïs, Da D. F., Yerbanga S. R., Morlais Isabelle, Awono-Ambene P. H., Dabire R. K., Ouedraogo J. B., Lefèvre Thierry, Churcher T. S., Cohuet Anna
Source
International Journal for Parasitology, 2020, 50 (12), p. 985-996 ISSN 0020-7519
The population dynamics of human to mosquito malaria transmission in the field has important implications for the genetics, epidemiology and control of malaria. The number of oocysts in oocyst-positive mosquitoes developing from a single, naturally acquired infectious blood meal (herein referred to as a single-feed infection load) greatly influences the efficacy of transmission blocking interventions but still remains poorly documented. During a year-long analysis of malaria parasite transmission in Burkina Faso we caught and dissected wild malaria vectors to assess Plasmodium oocyst prevalence and load (the number of oocysts counted in mosquitoes with detectable oocysts) and the prevalence of salivary gland sporozoites. This was compared with malaria endemicity in the human population, assessed in cross-sectional surveys. Data were analysed using a novel transmission mathematical model to estimate the per bite transmission probability and the average single-feed infection load for each location. The observed oocyst load and the estimated single-feed infection load in naturally infected mosquitoes were substantially higher than previous estimates (means ranging from 3.2 to 24.5 according to seasons and locations) and indicate a strong positive association between the single-feed infection load and parasite prevalence in humans. This work suggests that highly infected mosquitoes are not rare in the field and might have a greater influence on the epidemiology and genetics of the parasite, and on the efficacy of novel transmission blocking interventions.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010079876]
Identifiant IRD
fdi:010079876
Contact