@article{fdi:010079876,
  title = {{H}igh {P}lasmodium infection intensity in naturally infected malaria vectors in {A}frica},
  author = {{B}ompard, {A}na{\¨ie}s and {D}a, {D}. {F}. and {Y}erbanga, {S}. {R}. and {M}orlais, {I}sabelle and {A}wono-{A}mbene, {P}. {H}. and {D}abire, {R}. {K}. and {O}uedraogo, {J}. {B}. and {L}ef{\`e}vre, {T}hierry and {C}hurcher, {T}. {S}. and {C}ohuet, {A}nna},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he population dynamics of human to mosquito malaria transmission in the field has important implications for the genetics, epidemiology and control of malaria. {T}he number of oocysts in oocyst-positive mosquitoes developing from a single, naturally acquired infectious blood meal (herein referred to as a single-feed infection load) greatly influences the efficacy of transmission blocking interventions but still remains poorly documented. {D}uring a year-long analysis of malaria parasite transmission in {B}urkina {F}aso we caught and dissected wild malaria vectors to assess {P}lasmodium oocyst prevalence and load (the number of oocysts counted in mosquitoes with detectable oocysts) and the prevalence of salivary gland sporozoites. {T}his was compared with malaria endemicity in the human population, assessed in cross-sectional surveys. {D}ata were analysed using a novel transmission mathematical model to estimate the per bite transmission probability and the average single-feed infection load for each location. {T}he observed oocyst load and the estimated single-feed infection load in naturally infected mosquitoes were substantially higher than previous estimates (means ranging from 3.2 to 24.5 according to seasons and locations) and indicate a strong positive association between the single-feed infection load and parasite prevalence in humans. {T}his work suggests that highly infected mosquitoes are not rare in the field and might have a greater influence on the epidemiology and genetics of the parasite, and on the efficacy of novel transmission blocking interventions.},
  keywords = {{M}alaria ; {O}ocyst load ; {S}ingle-feed infection load ; {S}porozoite rate ; {W}ild mosquitoes ; {T}ransmission dynamics ; {T}ransmission-blocking vaccines},
  booktitle = {},
  journal = {{I}nternational {J}ournal for {P}arasitology},
  volume = {50},
  numero = {12},
  pages = {985--996},
  ISSN = {0020-7519},
  year = {2020},
  DOI = {10.1016/j.ijpara.2020.05.012},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079876},
}