Publications des scientifiques de l'IRD

Diop F., Alout H., Diagne C. T., Bengue M., Baronti Cécile, Hamel Rodolphe, Talignani L., Liégeois Florian, Pompon Julien, Vargas R. E. M., Nougairede A., Missé Dorothée. (2019). Differential susceptibility and innate immune response of Aedes aegypti and Aedes albopictus to the Haitian strain of the Mayaro virus. Viruses, 11 (10), art. 924 [11 p.].

Titre du document
Differential susceptibility and innate immune response of Aedes aegypti and Aedes albopictus to the Haitian strain of the Mayaro virus
Année de publication
2019
Type de document
Article référencé dans le Web of Science WOS:000498400400045
Auteurs
Diop F., Alout H., Diagne C. T., Bengue M., Baronti Cécile, Hamel Rodolphe, Talignani L., Liégeois Florian, Pompon Julien, Vargas R. E. M., Nougairede A., Missé Dorothée
Source
Viruses, 2019, 11 (10), art. 924 [11 p.]
Mayaro (MAYV) is an emerging arthropod-borne virus belonging to the Alphavirus genus of the Togaviridae family. Although forest-dwelling Haemagogus mosquitoes have been considered as its main vector, the virus has also been detected in circulating Aedes ssp mosquitoes. Here we assess the susceptibility of Aedes aegypti and Aedes albopictus to infection with MAYV and their innate immune response at an early stage of infection. Aedes albopictus was more susceptible to infection with MAYV than Ae. aegypti. Analysis of transcript levels of twenty immunity-related genes by real-time PCR in the midgut of both mosquitoes infected with MAYV revealed increased expression of several immune genes, including CLIP-domain serine proteases, the anti-microbial peptides defensin A, E, cecropin E, and the virus inducible gene. The regulation of certain genes appeared to be Aedes species-dependent. Infection of Ae. aegypti with MAYV resulted in increased levels of myeloid differentiation2-related lipid recognition protein (ML26A) transcripts, as compared to Ae. albopictus. Increased expression levels of thio-ester-containing protein 22 (TEP22) and Niemann-Pick type C1 (NPC1) gene transcripts were observed in infected Ae. albopictus, but not Ae. aegypti. The differences in these gene expression levels during MAYV infection could explain the variation in susceptibility observed in both mosquito species.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BRESIL ; HAITI
Localisation
Fonds IRD [F B010077378]
Identifiant IRD
fdi:010077378
Contact