Publications des scientifiques de l'IRD

Traoré Dipomin, Sagna A. B., Adja A. M., Zoh D. D., Lingue K. N., Coulibaly I., Tchiekoi B. N., Assi S. B., Poinsignon Anne, Dagnogo M., Remoué Franck. (2018). Evaluation of malaria urban risk using an immuno-epidemiological biomarker of human exposure to anopheles bites. American Journal of Tropical Medicine and Hygiene, 98 (5), p. 1353-1359. ISSN 0002-9637.

Titre du document
Evaluation of malaria urban risk using an immuno-epidemiological biomarker of human exposure to anopheles bites
Année de publication
2018
Type de document
Article référencé dans le Web of Science WOS:000433037800025
Auteurs
Traoré Dipomin, Sagna A. B., Adja A. M., Zoh D. D., Lingue K. N., Coulibaly I., Tchiekoi B. N., Assi S. B., Poinsignon Anne, Dagnogo M., Remoué Franck
Source
American Journal of Tropical Medicine and Hygiene, 2018, 98 (5), p. 1353-1359 ISSN 0002-9637
Urban malaria is an underestimated serious health concern in African countries. This study aimed to evaluate the risk of malaria transmission in an urban area by evaluating the level of human exposure to Anopheles bites using an Anopheles salivary biomarker (gambiae Salivary Gland Protein-6 peptide 1 [gSG6-P1] peptide). Two multidisciplinary cross-sectional studies were undertaken in five sites of Bouake city (three urban districts and two surrounding villages, used as control; Cote d'Ivoire) during the rainy season and the dry season. Blood samples were obtained from children 6 months to 14 years of age for immunological tests. The level of anti-gSG6-P1 immunoglobulin G (IgG) antibodies was significantly higher in the rainy season than the dry season in both urban and rural sites (P < 0.0001). Interestingly, children with the highest anti-gSG6-P1 IgG responses in the rainy season were infected by Plasmodium falciparum. Surprisingly, no difference of anti-gSG6-P1 IgG level was observed between urban and rural areas, for either season. The current data suggest that children in the urban city of Bouake ' could be as highly exposed to Anopheles bites as children living in surrounding villages. The immunological biomarker of human exposure to Anopheles bites may be used to accurately assess the potential risk of malaria transmission in African urban settings.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010073038]
Identifiant IRD
fdi:010073038
Contact