Cubry Philippe, Scotti I., Oddou-Muratorio S., Lefevre F. (2017). Generalization of the Q(ST) framework in hierarchically structured populations : impacts of inbreeding and dominance. Molecular Ecology Resources, 17 (6), p. e76-e83. ISSN 1755-098X.
Titre du document
Generalization of the Q(ST) framework in hierarchically structured populations : impacts of inbreeding and dominance
Cubry Philippe, Scotti I., Oddou-Muratorio S., Lefevre F.
Source
Molecular Ecology Resources, 2017,
17 (6), p. e76-e83 ISSN 1755-098X
Q(ST) is a differentiation parameter based on the decomposition of the genetic variance of a trait. In the case of additive inheritance and absence of selection, it is analogous to the genic differentiation measured on individual loci, F-ST. Thus, Q(ST)-F-ST comparison is used to infer selection: selective divergence when Q(ST)>F-ST, or convergence when Q(ST)0 (higher when F-IS<0). Then, we used an island model simulation approach to investigate the impact of inbreeding and dominance on the Q(ST)-F-ST framework in a hierarchical population structure. We show that, while differentiation at the lower hierarchical level (Q(SR)) is a monotonic function of migration, differentiation at the upper level (Q(RT)) is not. In the case of additive inheritance, we show that inbreeding inflates the variance of Q(RT), which can increase the frequency of Q(RT)>F-RT cases. We also show that dominance drastically reduces Q-statistics below F-statistics for any level of the hierarchy. Therefore, high values of Q-statistics are good indicators of selection, but low values are not in the case of dominance.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
