Leman-Loubière C., Le Goff G., Retailleau P., Debitus Cécile, Ouazzani J. (2017). Sporothriolide-related compounds from the fungus Hypoxylon monticulosum CLL-205 isolated from a Sphaerocladina sponge from the Tahiti Coast. Journal of Natural Products, 80 (10), p. 2850-2854. ISSN 0163-3864.
Titre du document
Sporothriolide-related compounds from the fungus Hypoxylon monticulosum CLL-205 isolated from a Sphaerocladina sponge from the Tahiti Coast
Leman-Loubière C., Le Goff G., Retailleau P., Debitus Cécile, Ouazzani J.
Source
Journal of Natural Products, 2017,
80 (10), p. 2850-2854 ISSN 0163-3864
Two sporothriolide-related compounds were obtained from an extract of the fungus Hypoxylon monticulosum CLL-205, isolated from a Sphaerocladina sponge collected from the Tahiti coast. Compound 2 is a deoxy analogue of sporothric acid (4). Compound 3 is a newly reported unusual scaffold combining sporothriolide (1) and trienylfuranol A (5) moieties, through a Diels-Alderase-type reaction. Various experimental and analytical arguments supported the biocatalytic origin of compound 3. The structures of the isolated compounds were elucidated using 1D and 2D NMR, HRMS, and IR data. The structure and the absolute configuration of 3 were unambiguously confirmed by a single-crystal X-ray diffraction analysis.
