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Gopalan S., Carja O., Fagny M., Patin E., Myrick J. W., McEwen L. M., Mah S. M., Kobor M. S., Froment Alain, Feldman M. W., Quintana-Murci L., Henn B. M. (2017). Trends in DNA methylation with age replicate across diverse human populations. Genetics, 206 (3), 1659-1674. ISSN 0016-6731

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Lien direct chez l'éditeur doi:10.1534/genetics.116.195594

Titre
Trends in DNA methylation with age replicate across diverse human populations
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000404981600035
AuteursGopalan S., Carja O., Fagny M., Patin E., Myrick J. W., McEwen L. M., Mah S. M., Kobor M. S., Froment Alain, Feldman M. W., Quintana-Murci L., Henn B. M.
SourceGenetics, 2017, 206 (3), p. 1659-1674. ISSN 0016-6731
RésuméAging is associated with widespread changes in genome-wide patterns of DNA methylation. Thousands of CpG sites whose tissue-specific methylation levels are strongly correlated with chronological age have been previously identified. However, the majority of these studies have focused primarily on cosmopolitan populations living in the developed world; it is not known if age-related patterns of DNA methylation at these loci are similar across a broad range of human genetic and ecological diversity. We investigated genome-wide methylation patterns using saliva-and whole blood-derived DNA from two traditionally hunting and gathering African populations: the Baka of the western Central African rain forest and the not equal Khomani San of the South African Kalahari Desert. We identified hundreds of CpG sites whose methylation levels are significantly associated with age, thousands that are significant in a meta-analysis, and replicate trends previously reported in populations of non-African descent. We confirmed that an age-associated site in the promoter of the gene ELOVL2 shows a remarkably congruent relationship with aging in humans, despite extensive genetic and environmental variation across populations. We also demonstrate that genotype state at methylation quantitative trait loci (meQTLs) can affect methylation trends at some age-associated CpG sites. Our study explores the relationship between CpG methylation and chronological age in populations of African hunter-gatherers, who rely on different diets across diverse ecologies. While many age-related CpG sites replicate across populations, we show that considering common genetic variation at meQTLs further improves our ability to detect previously identified age associations.
Plan de classementSanté : généralités [050] ; Sciences fondamentales / Techniques d'analyse et de recherche [020]
Descr. géo.AFRIQUE DU SUD ; GABON ; CAMEROUN ; EUROPE
LocalisationFonds IRD [F B010070369]
Identifiant IRDfdi:010070369
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010070369

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