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Delory T., Ngo-Giang-Huong Nicole, Rangdaeng S., Chotivanich N., Limtrakul A., Putiyanun C., Suriyachai P., Matanasarawut W., Jarupanich T., Liampongsabuddhi P., Heard I., Jourdain Gonzague, Lallemant Marc, Le Coeur S., PapilloV Study Group. (2017). Human Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand. Journal of Infection, 74 (5), 501-511. ISSN 0163-4453

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Lien direct chez l'éditeur doi:10.1016/j.jinf.2017.02.007

Titre
Human Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000399488700009
AuteursDelory T., Ngo-Giang-Huong Nicole, Rangdaeng S., Chotivanich N., Limtrakul A., Putiyanun C., Suriyachai P., Matanasarawut W., Jarupanich T., Liampongsabuddhi P., Heard I., Jourdain Gonzague, Lallemant Marc, Le Coeur S., PapilloV Study Group.
SourceJournal of Infection, 2017, 74 (5), p. 501-511. ISSN 0163-4453
RésuméObjectives: To estimate the prevalence and factors associated with Human Papillomavirus (HPV) infection, HPV genotypes and cytological/histological high-grade (HSIL+/ CIN2+) lesions. Methods: We conducted a cross-sectional study within a prospective cohort of HIV-infected women on combination antiretroviral therapy (cART). Cervical specimens were collected for cytology and HPV genotyping (Papillocheck (R)). Any women with High-Risk-HPV (HR-HPV), and/or potentially HR-HPV (pHR-HPV) and/or ASC-US or higher (ASC-US+) lesions were referred for colposcopy. Factors associated with HR-HPV infection and with HSIL+/CIN2+ lesions were investigated using mixed-effects logistic regression models. Results: 829 women were enrolled: median age 40.4 years, on cART for a median of 6.9 years, median CD4 cell-count 536 cells/mm3, and 788 (96%) with HIV-viral load< 50copies/mL. Of 214 (26%) infected with HPV: 159 (19%) had >= 1 HR-HPV, of whom 38 (5%) HPV52, 22 (3%) HPV16, 9 (1%) HPV18; 21 (3%) had pHR-HPV, 34 (4%) low risk-HPV infection, and 56 (26%) had multiple genotypes. Younger age, low CD4 cell-counts and low education were independently associated with HR-HPV infection. 72 women (9%) had ASC-US+ and 28 (3%) HSIL+/CIN2+ lesions. HR-HPV infection was independently associated with HSIL+/CIN2+ lesions. Conclusion: The prevalence of HPV infection and of cervical lesions was low. The HPV genotype distribution supports the use of 9-valent vaccine in Thailand.
Plan de classementSanté : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Descr. géo.THAILANDE
LocalisationFonds IRD [F B010069963]
Identifiant IRDfdi:010069963
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010069963

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