%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Delory, T.
%A Ngo-Giang-Huong, Nicole
%A Rangdaeng, S.
%A Chotivanich, N.
%A Limtrakul, A.
%A Putiyanun, C.
%A Suriyachai, P.
%A Matanasarawut, W.
%A Jarupanich, T.
%A Liampongsabuddhi, P.
%A Heard, I.
%A Jourdain, Gonzague
%A Lallemant, Marc
%A Le Coeur, S.
%A PapilloV Study Group,
%T Human Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand
%D 2017
%L fdi:010069963
%G ENG
%J Journal of Infection
%@ 0163-4453
%K HPV ; HIV ; Women ; Thailand ; Cervical lesions ; Cancer ; Antiretroviral therapy ; Cross-sectional study
%K THAILANDE
%M ISI:000399488700009
%N 5
%P 501-511
%R 10.1016/j.jinf.2017.02.007
%U https://www.documentation.ird.fr/hor/fdi:010069963
%> https://www.documentation.ird.fr/intranet/publi/2017/05/010069963.pdf
%V 74
%W Horizon (IRD)
%X Objectives: To estimate the prevalence and factors associated with Human Papillomavirus (HPV) infection, HPV genotypes and cytological/histological high-grade (HSIL+/ CIN2+) lesions. Methods: We conducted a cross-sectional study within a prospective cohort of HIV-infected women on combination antiretroviral therapy (cART). Cervical specimens were collected for cytology and HPV genotyping (Papillocheck (R)). Any women with High-Risk-HPV (HR-HPV), and/or potentially HR-HPV (pHR-HPV) and/or ASC-US or higher (ASC-US+) lesions were referred for colposcopy. Factors associated with HR-HPV infection and with HSIL+/CIN2+ lesions were investigated using mixed-effects logistic regression models. Results: 829 women were enrolled: median age 40.4 years, on cART for a median of 6.9 years, median CD4 cell-count 536 cells/mm3, and 788 (96%) with HIV-viral load< 50copies/mL. Of 214 (26%) infected with HPV: 159 (19%) had >= 1 HR-HPV, of whom 38 (5%) HPV52, 22 (3%) HPV16, 9 (1%) HPV18; 21 (3%) had pHR-HPV, 34 (4%) low risk-HPV infection, and 56 (26%) had multiple genotypes. Younger age, low CD4 cell-counts and low education were independently associated with HR-HPV infection. 72 women (9%) had ASC-US+ and 28 (3%) HSIL+/CIN2+ lesions. HR-HPV infection was independently associated with HSIL+/CIN2+ lesions. Conclusion: The prevalence of HPV infection and of cervical lesions was low. The HPV genotype distribution supports the use of 9-valent vaccine in Thailand.
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