Bork Kirsten, Cames Cécile, Newell M. L., Read J. S., Ayassou K., Musyoka F., Mbatia G., Cournil Amandine, Kesho Bora Study Group (collab.). (2017). Formula-feeding of HIV-exposed uninfected African children is associated with faster growth in length during the first 6 months of life in the Kesho Bora Study. Journal of Nutrition, 147 (3), p. 453-461. ISSN 0022-3166.
Titre du document
Formula-feeding of HIV-exposed uninfected African children is associated with faster growth in length during the first 6 months of life in the Kesho Bora Study
Année de publication
2017
Auteurs
Bork Kirsten, Cames Cécile, Newell M. L., Read J. S., Ayassou K., Musyoka F., Mbatia G., Cournil Amandine, Kesho Bora Study Group
Source
Journal of Nutrition, 2017,
147 (3), p. 453-461 ISSN 0022-3166
Background: Early feeding patternsmay affect the growth of HIV-exposed children and thus their subsequent health and cognition. Objective: We assessed the association of infant feeding (IF) mode with length-for-age z score (LAZ) and stunting fromage 2 d to 18 mo in HIV-exposed African childrenwithin a controlled randomized trial, which evaluated triple antiretrovirals initiated during pregnancy and continued for 6 mo postpartum to prevent HIV transmission. Methods: HIV-infected pregnant women with CD4 + counts of 200-500 cells/mm(3) from Burkina Faso, Kenya, and South Africa were advised to exclusively breastfeed for up to 6 mo or to formula-feed from birth. Factors associated with LAZ were investigated in all uninfected children by using mixed-effects linear models; those associated with stunting (LAZ < 22) at 6 or 12 mo were assessed in multiple logistic regression after exclusion of children stunted at age 2 d. Independent variables were IF mode: formula feeding (FF), exclusive breastfeeding (EBF) < 3 mo, or EBF 3 mo (reference); sex; trial arm; maternal characteristics; and site. Results: Among 728 children, FF was associated with a greater increase in LAZ from 2 d to 6 mo (+ 0.07 z score/mo, P < 0.001). Between 6 and 18 mo, FF and EBF < 3mowere both associated with greatermean LAZ than was EBF 3mo (+ 0.52z scores and + 0.43 z scores, respectively, P < 0.001). Among children not stunted at 2 d, FF was independently associatedwith a reduced risk of stunting at 6mo (OR: 0.24; 95% CI: 0.07, 0.81; P = 0.021), whereas EBF < 3 mo was not (OR: 0.49; 95% CI: 0.22, 1.10; P= 0.09). Conclusions: In this observational study of HIV-exposed uninfected infants, growth in length in the first 6mo of lifewas faster in formula-fed infants than in exclusively breastfed infants. The plausibility of
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
;
Nutrition, alimentation [054]
Description Géographique
BURKINA FASO ; KENYA ; AFRIQUE DU SUD
Localisation
Fonds IRD [F B010069427]
Identifiant IRD
fdi:010069427
