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Tuikue Ndam Nicaise, Basco Leonardo, Ngane V. F., Ayouba Ahidjo, Ngolle E. M., Deloron Philippe, Peeters Martine, Tahar Rachida. (2017). Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon. Malaria Journal, 16, p. art. 130 [6 p.]. ISSN 1475-2875.

Titre du document
Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon
Année de publication
2017
Type de document
Article référencé dans le Web of Science WOS:000397735600001
Auteurs
Tuikue Ndam Nicaise, Basco Leonardo, Ngane V. F., Ayouba Ahidjo, Ngolle E. M., Deloron Philippe, Peeters Martine, Tahar Rachida
Source
Malaria Journal, 2017, 16, p. art. 130 [6 p.] ISSN 1475-2875
Background: Chloroquine had been used extensively during the last five decades in Cameroon. Its decreasing clinical effectiveness, supported by high proportions of clinical isolates carrying the mutant pfcrt haplotype (CVIET), led the health authorities to resort to amodiaquine monotherapy in 2002 and artemisinin-based combination therapy (ACT) in 2004 (artesunate-amodiaquine, with artemether-lumefantrine as an alternative since 2006) as the first-line treatment of uncomplicated malaria. The aim of the present study was to investigate whether the withdrawal of chloroquine was associated with a reduction in pfcrt mutant parasite population and reemergence of chloroquinesensitive parasites in southeastern Cameroon between 2003 and 2012. Methods: The frequency of pfcrt haplotypes at positions 72-76 in Plasmodium falciparum isolates collected from individuals in 2003 and 2012 in southeastern Cameroon was determined by sequence specific oligonucleotide probes-enzyme linked immunosorbent assay (SSOP-ELISA). Results: The proportions of parasites carrying the mutant haplotype CVIET and the wild-type CVMNK were 53.0 and 28.0% in 2003, respectively. The proportion of the mutant haplotype in samples collected 9 years later decreased to 25.3% whereas the proportion of parasites carrying the wild-type CVMNK haplotype was 53.7%. Conclusions: Even though the proportion of chloroquine-sensitive parasites seems to be increasing in southeastern Cameroon, a reintroduction of chloroquine cannot be recommended at present in Cameroon. The current national anti-malarial drug policy should be implemented and reinforced to combat drug-resistant malaria.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde végétal [076]
Description Géographique
CAMEROUN
Localisation
Fonds IRD [F B010069413]
Identifiant IRD
fdi:010069413
Contact