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Rhoné Bénédicte, Mariac Cédric, Couderc Marie, Berthouly Cécile, Ousseini I. S., Vigouroux Yves. (2017). No excess of cis-regulatory variation associated with intraspecific selection in wild pearl millet (Cenchrus americanus). Genome Biology and Evolution, 9 (2), 388-397. ISSN 1759-6653

Fichier PDF disponible http://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-04/010069377.pdf

Lien direct chez l'éditeur doi:10.1093/gbe/evx004

Titre
No excess of cis-regulatory variation associated with intraspecific selection in wild pearl millet (Cenchrus americanus)
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000396058400018
AuteursRhoné Bénédicte, Mariac Cédric, Couderc Marie, Berthouly Cécile, Ousseini I. S., Vigouroux Yves.
SourceGenome Biology and Evolution, 2017, 9 (2), p. 388-397. ISSN 1759-6653
RésuméSeveral studies suggestthat cis-regulatory mutations are the favorite target of evolutionary changes, one reason being that cis-regulatory mutations might have fewer deleterious pleiotropic effects than protein-coding mutations. A review of the process also suggests that this bias towards adaptive cis-regulatory variation might be less pronounced at the intraspecific level compared with the interspecific level. In this study, we assessed the contribution of cis-regulatory variation to adaptation at the intraspecific level using populations of wild pearl millet (Cenchrus americanus ssp. monodii) sampled along an environmental gradient in Niger. From RNA sequencing of hybrids to assess allele-specific expression, we identified genes with cis-regulatory divergence between two parental accessions collected in contrasted environmental conditions. This revealed that similar to 15% of transcribed genes showed cis-regulatory variation. Intersecting the gene set exhibiting cis-regulatory variation with the gene set identified as targets of selection revealed no excess of cis-acting mutations among the selected genes. We additionally found no excess of cis-regulatory variation among genes associated with adaptive traits. As our approach relied on methods identifying mainly genes submitted to strong selection pressure or with high phenotypic effect, the contribution of cis-regulatory changes to soft selection or polygenic adaptive traits remains to be tested. However our results favor the hypothesis that enrichment of adaptive cis-regulatory divergence builds up over time. For short evolutionary time-scales, cis-acting mutations are not predominantly involved in adaptive evolution associated with strong selective signal.
Plan de classementSciences du monde végétal [076]
Descr. géo.NIGER
LocalisationFonds IRD [F B010069377]
Identifiant IRDfdi:010069377
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010069377

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