Zebiri I., Haddad Mohamed, Duca L., Sauvain Michel, Paloque L., Cabanillas B., Rengifo E., Behr J. B., Voutquenne-Nazabadioko L. (2017). Biological activities of triterpenoids from Poraqueiba sericea stems. Natural Product Research, 31 (11), p. 1333-1338. ISSN 1478-6419.
Titre du document
Biological activities of triterpenoids from Poraqueiba sericea stems
Année de publication
2017
Auteurs
Zebiri I., Haddad Mohamed, Duca L., Sauvain Michel, Paloque L., Cabanillas B., Rengifo E., Behr J. B., Voutquenne-Nazabadioko L.
Source
Natural Product Research, 2017,
31 (11), p. 1333-1338 ISSN 1478-6419
Eleven compounds were isolated from Poraqueiba sericea stems and identified as niga-ichigoside-F1 (1), trachelosperoside B1 (2), 4-epi-niga-ichigoside (7), 19-hydroxyasiatic acid (3), myrianthic acid (4), hyptatic acid (5), trachelosperogenin B (6), arjunolic acid (8), and trachelosperogenin E (9), secologanoside (10) and secoxyloganin (11). Compounds 1-11 were tested for their antileishmanial activities against Leishmania infantum promastigotes, 1-6 and 8-11 were tested for their cytotoxic activities on fibroblasts, 1-3, 5-6, 8-11 were evaluated for their anti-elastase and anti-acetylcholinesterase assays activities by a spectrophotometric method and 1-2, 5 and 7-10 were tested using bioautography for their -glucosidase. No antileishmanial activity was detected; compounds 1, 2 and 11 showed a moderate cytotoxic activity with IC50 17.7, 20.5 and 10.9g/mL, respectively; compounds 2, 8, 9 and 10 gave a percentage of inhibition ranging from 13 to 16% (at 50g/mL) and compounds 1 and 2 showed an inhibition zone on -glucosidase and anti-acetylcholinesterase assays. [GRAPHICS]
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Sciences du monde végétal [076]
Description Géographique
PEROU
Localisation
Fonds IRD [F B010069351]
Identifiant IRD
fdi:010069351
