%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Zebiri, I.
%A Haddad, Mohamed
%A Duca, L.
%A Sauvain, Michel
%A Paloque, L.
%A Cabanillas, B.
%A Rengifo, E.
%A Behr, J. B.
%A Voutquenne-Nazabadioko, L.
%T Biological activities of triterpenoids from Poraqueiba sericea stems
%D 2017
%L fdi:010069351
%G ENG
%J Natural Product Research
%@ 1478-6419
%K Poraqueiba sericea ; Icacinaceae ; triterpenes ; secoiridoids
%K PEROU
%M ISI:000395160000017
%N 11
%P 1333-1338
%R 10.1080/14786419.2016.1241998
%U https://www.documentation.ird.fr/hor/fdi:010069351
%> https://www.documentation.ird.fr/intranet/publi/2017/04/010069351.pdf
%V 31
%W Horizon (IRD)
%X Eleven compounds were isolated from Poraqueiba sericea stems and identified as niga-ichigoside-F1 (1), trachelosperoside B1 (2), 4-epi-niga-ichigoside (7), 19-hydroxyasiatic acid (3), myrianthic acid (4), hyptatic acid (5), trachelosperogenin B (6), arjunolic acid (8), and trachelosperogenin E (9), secologanoside (10) and secoxyloganin (11). Compounds 1-11 were tested for their antileishmanial activities against Leishmania infantum promastigotes, 1-6 and 8-11 were tested for their cytotoxic activities on fibroblasts, 1-3, 5-6, 8-11 were evaluated for their anti-elastase and anti-acetylcholinesterase assays activities by a spectrophotometric method and 1-2, 5 and 7-10 were tested using bioautography for their -glucosidase. No antileishmanial activity was detected; compounds 1, 2 and 11 showed a moderate cytotoxic activity with IC50 17.7, 20.5 and 10.9g/mL, respectively; compounds 2, 8, 9 and 10 gave a percentage of inhibition ranging from 13 to 16% (at 50g/mL) and compounds 1 and 2 showed an inhibition zone on -glucosidase and anti-acetylcholinesterase assays. [GRAPHICS]
%$ 076 ; 020 ; 050