Publications des scientifiques de l'IRD

Chesnais C. B., Sabbagh A., Pion Sébastien, Missamou F., Garcia André, Boussinesq Michel. (2016). Familial aggregation and heritability of Wuchereria bancrofti infection. Journal of Infectious Diseases, 214 (4), p. 587-594. ISSN 0022-1899.

Titre du document
Familial aggregation and heritability of Wuchereria bancrofti infection
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000384849600011
Auteurs
Chesnais C. B., Sabbagh A., Pion Sébastien, Missamou F., Garcia André, Boussinesq Michel
Source
Journal of Infectious Diseases, 2016, 214 (4), p. 587-594 ISSN 0022-1899
Background. The familial recurrence risk of lymphatic filariasis (LF) is unknown. This case study aimed to evaluate the familial susceptibility to infection with Wuchereria bancrofti and to microfilaremia in a village of the Republic of Congo. Methods. The heritability and intrafamilial correlation coefficients were assessed for both W bancrofti infection and microfilaremia by controlling for individual risk factors, environmental influence, and household effects. Results. Pedigree charts were constructed for 829 individuals, including 143 individuals with a diagnosis of W bancrofti circulating filarial antigens (CFAs) and 44 who also had microfilariae (MF). There was no intrafamilial correlation regarding CFA levels. However, the presence of MF (rho = 0.45) and microfilarial density (rho = 0.44) were significantly correlated among parent-offspring pairs. Heritability estimates for CFA positivity and intensity were 0.23 and 0.18, respectively. Heritability estimates were high for microfilarial positivity (h(2) = 0.74) and microfilarial density traits (h(2) = 0.81). Conclusions. Our study suggests that the acquisition of LF is mainly driven by environmental factors and habits and that genetic factors are moderately involved in the regulation of infection. By contrast, genetic factors play a major role in both the presence and intensity of microfilaremia.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CONGO
Localisation
Fonds IRD [F B010068225]
Identifiant IRD
fdi:010068225
Contact