@article{fdi:010068225,
  title = {{F}amilial aggregation and heritability of {W}uchereria bancrofti infection},
  author = {{C}hesnais, {C}. {B}. and {S}abbagh, {A}. and {P}ion, {S}{\'e}bastien and {M}issamou, {F}. and {G}arcia, {A}ndr{\'e} and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}he familial recurrence risk of lymphatic filariasis ({LF}) is unknown. {T}his case study aimed to evaluate the familial susceptibility to infection with {W}uchereria bancrofti and to microfilaremia in a village of the {R}epublic of {C}ongo. {M}ethods. {T}he heritability and intrafamilial correlation coefficients were assessed for both {W} bancrofti infection and microfilaremia by controlling for individual risk factors, environmental influence, and household effects. {R}esults. {P}edigree charts were constructed for 829 individuals, including 143 individuals with a diagnosis of {W} bancrofti circulating filarial antigens ({CFA}s) and 44 who also had microfilariae ({MF}). {T}here was no intrafamilial correlation regarding {CFA} levels. {H}owever, the presence of {MF} (rho = 0.45) and microfilarial density (rho = 0.44) were significantly correlated among parent-offspring pairs. {H}eritability estimates for {CFA} positivity and intensity were 0.23 and 0.18, respectively. {H}eritability estimates were high for microfilarial positivity (h(2) = 0.74) and microfilarial density traits (h(2) = 0.81). {C}onclusions. {O}ur study suggests that the acquisition of {LF} is mainly driven by environmental factors and habits and that genetic factors are moderately involved in the regulation of infection. {B}y contrast, genetic factors play a major role in both the presence and intensity of microfilaremia.},
  keywords = {lymphatic filariasis ; heritability ; familial aggregation ; genetic susceptibility ; {CONGO}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {214},
  numero = {4},
  pages = {587--594},
  ISSN = {0022-1899},
  year = {2016},
  DOI = {10.1093/infdis/jiw212},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068225},
}