Publications des scientifiques de l'IRD

Drame P. M., Poinsignon Anne, Dechavanne C., Cottrell Gilles, Farce M., Ladekpo R., Massougbodji A., Cornélie Sylvie, Courtin David, Migot Nabias Florence, Garcia André, Remoué Franck. (2015). Specific antibodies to Anopheles gSG6-P1 salivary peptide to assess early childhood exposure to malaria vector bites. Malaria Journal, 14, 285 [9 p.]. ISSN 1475-2875.

Titre du document
Specific antibodies to Anopheles gSG6-P1 salivary peptide to assess early childhood exposure to malaria vector bites
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000358275600004
Auteurs
Drame P. M., Poinsignon Anne, Dechavanne C., Cottrell Gilles, Farce M., Ladekpo R., Massougbodji A., Cornélie Sylvie, Courtin David, Migot Nabias Florence, Garcia André, Remoué Franck
Source
Malaria Journal, 2015, 14, 285 [9 p.] ISSN 1475-2875
Background: The estimates of risk of malaria in early childhood are imprecise given the current entomologic and parasitological tools. Thus, the utility of anti-Anopheles salivary gSG6-P1 peptide antibody responses in measuring exposure to Anopheles bites during early infancy has been assessed. Methods: Anti-gSG6-P1 IgG and IgM levels were evaluated in 133 infants (in Benin) at three (M3), six (M6), nine (M9) and 12 (M12) months of age. Specific IgG levels were also assessed in their respective umbilical cord blood (IUCB) and maternal blood (MPB). Results: At M3, 93.98 and 41.35% of infants had anti-gSG6-P1 IgG and IgM Ab, respectively. Specific median IgG and IgM levels gradually increased between M3 and M6 (p < 0.0001 and p < 0.001), M6-M9 (p < 0.0001 and p = 0.085) and M9-M12 (p = 0.002 and p = 0.03). These levels were positively associated with the Plasmodium falciparum infection intensity (p = 0.006 and 0.003), and inversely with the use of insecticide-treated bed nets (p = 0.003 and 0.3). Levels of specific IgG in the MPB were positively correlated to those in the IUCB (R = 0.73; p < 0.0001) and those at M3 (R = 0.34; p < 0.0001). Conclusion: The exposure level to Anopheles bites, and then the risk of malaria infection, can be evaluated in young infants by assessing anti-gSG6-P1 IgM and IgG responses before and after 6-months of age, respectively. This tool can be useful in epidemiological evaluation and surveillance of malaria risk during the first year of life.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE ; BENIN
Localisation
Fonds IRD [F B010064846]
Identifiant IRD
fdi:010064846
Contact