@article{fdi:010064846,
  title = {{S}pecific antibodies to {A}nopheles g{SG}6-{P}1 salivary peptide to assess early childhood exposure to malaria vector bites},
  author = {{D}rame, {P}. {M}. and {P}oinsignon, {A}nne and {D}echavanne, {C}. and {C}ottrell, {G}illes and {F}arce, {M}. and {L}adekpo, {R}. and {M}assougbodji, {A}. and {C}orn{\'e}lie, {S}ylvie and {C}ourtin, {D}avid and {M}igot {N}abias, {F}lorence and {G}arcia, {A}ndr{\'e} and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he estimates of risk of malaria in early childhood are imprecise given the current entomologic and parasitological tools. {T}hus, the utility of anti-{A}nopheles salivary g{SG}6-{P}1 peptide antibody responses in measuring exposure to {A}nopheles bites during early infancy has been assessed. {M}ethods: {A}nti-g{SG}6-{P}1 {I}g{G} and {I}g{M} levels were evaluated in 133 infants (in {B}enin) at three ({M}3), six ({M}6), nine ({M}9) and 12 ({M}12) months of age. {S}pecific {I}g{G} levels were also assessed in their respective umbilical cord blood ({IUCB}) and maternal blood ({MPB}). {R}esults: {A}t {M}3, 93.98 and 41.35% of infants had anti-g{SG}6-{P}1 {I}g{G} and {I}g{M} {A}b, respectively. {S}pecific median {I}g{G} and {I}g{M} levels gradually increased between {M}3 and {M}6 (p < 0.0001 and p < 0.001), {M}6-{M}9 (p < 0.0001 and p = 0.085) and {M}9-{M}12 (p = 0.002 and p = 0.03). {T}hese levels were positively associated with the {P}lasmodium falciparum infection intensity (p = 0.006 and 0.003), and inversely with the use of insecticide-treated bed nets (p = 0.003 and 0.3). {L}evels of specific {I}g{G} in the {MPB} were positively correlated to those in the {IUCB} ({R} = 0.73; p < 0.0001) and those at {M}3 ({R} = 0.34; p < 0.0001). {C}onclusion: {T}he exposure level to {A}nopheles bites, and then the risk of malaria infection, can be evaluated in young infants by assessing anti-g{SG}6-{P}1 {I}g{M} and {I}g{G} responses before and after 6-months of age, respectively. {T}his tool can be useful in epidemiological evaluation and surveillance of malaria risk during the first year of life.},
  keywords = {{M}alaria ; {S}alivary proteins ; {B}iomarker of exposure ; {A}nopheles bites ; {M}aternal {I}g{G} transfer ; {I}nfants ; {A}frica ; {AFRIQUE} ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {14},
  numero = {},
  pages = {285 [9 ]},
  ISSN = {1475-2875},
  year = {2015},
  DOI = {10.1186/s12936-015-0800-6},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064846},
}