Thouvenin Y., Makinson A., Cournil Amandine, Eymard-Duvernay Sabrina, Lentz P., Delemazure A. S., Corneloup O., Fabre S., Quesnoy Mylène, Poire S., Brillet P. Y., Cyteval C., Reynes J., Le Moing V. (2015). Chest low-dose computed tomography for early lung cancer diagnosis as an opportunity to diagnose vertebral fractures in HIV-infected smokers, an ANRS EP48 HIV CHEST substudy. Jaids.Journal of Acquired Immune Deficiency Syndromes, 69 (3), p. 299-305. ISSN 1525-4135.
Titre du document
Chest low-dose computed tomography for early lung cancer diagnosis as an opportunity to diagnose vertebral fractures in HIV-infected smokers, an ANRS EP48 HIV CHEST substudy
Année de publication
2015
Auteurs
Thouvenin Y., Makinson A., Cournil Amandine, Eymard-Duvernay Sabrina, Lentz P., Delemazure A. S., Corneloup O., Fabre S., Quesnoy Mylène, Poire S., Brillet P. Y., Cyteval C., Reynes J., Le Moing V.
Source
Jaids.Journal of Acquired Immune Deficiency Syndromes, 2015,
69 (3), p. 299-305 ISSN 1525-4135
Background:To estimate the prevalence of vertebral fractures on chest low-dose computed tomography (LDCT) in HIV-infected smokers.Methods:Cross-sectional study of vertebral fractures visualized on chest LDCT from a multicenter prospective cohort evaluating feasibility of chest LDCT for early lung cancer diagnosis in HIV-infected subjects. Subjects were included if 40 years or older, had been active smokers within the last 3 years of at least 20 pack-years, and had a CD4 T-lymphocyte nadir cell count <350 per microliter and an actual CD4 T-cell count >100 cells per microliter. Spinal reconstructed sagittal planes obtained from chest axial native acquisitions were blindly read by a musculoskeletal imaging specialist. Assessment of the fractured vertebra used Genant semiquantitative method. The study end point was the prevalence of at least 1 vertebral fracture.Results:Three hundred ninety-seven subjects were included. Median age was 49.5 years, median smoking history was 30 pack-years, median last CD4 count was 584 cells per microliter, and median CD4 nadir count was 168 cells per microliter; 90% of subjects had a viral load below 50 copies per milliliter. At least 1 fracture was visible in 46 (11.6%) subjects. In multivariate analysis, smoking 40 packs-years [OR = 2.5; 95% CI: (1.2 to 5.0)] was associated with an increased risk of vertebral fracture, while HIV viral load <200 copies per milliliter [OR = 0.3; 95% CI: (0.1 to 0.9)] was protective.Conclusions:Prevalence of vertebral fractures on chest LDCT was 11.6% in this high-risk population. Smoking cessation and early introduction of antiretroviral therapy for prevention of vertebral fractures could be beneficial. Chest LDCT is an opportunity to diagnose vertebral fractures.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010064765]
Identifiant IRD
fdi:010064765
