@article{fdi:010064765,
  title = {{C}hest low-dose computed tomography for early lung cancer diagnosis as an opportunity to diagnose vertebral fractures in {HIV}-infected smokers, an {ANRS} {EP}48 {HIV} {CHEST} substudy},
  author = {{T}houvenin, {Y}. and {M}akinson, {A}. and {C}ournil, {A}mandine and {E}ymard-{D}uvernay, {S}abrina and {L}entz, {P}. and {D}elemazure, {A}. {S}. and {C}orneloup, {O}. and {F}abre, {S}. and {Q}uesnoy, {M}yl{\`e}ne and {P}oire, {S}. and {B}rillet, {P}. {Y}. and {C}yteval, {C}. and {R}eynes, {J}. and {L}e {M}oing, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground:{T}o estimate the prevalence of vertebral fractures on chest low-dose computed tomography ({LDCT}) in {HIV}-infected smokers.{M}ethods:{C}ross-sectional study of vertebral fractures visualized on chest {LDCT} from a multicenter prospective cohort evaluating feasibility of chest {LDCT} for early lung cancer diagnosis in {HIV}-infected subjects. {S}ubjects were included if 40 years or older, had been active smokers within the last 3 years of at least 20 pack-years, and had a {CD}4 {T}-lymphocyte nadir cell count <350 per microliter and an actual {CD}4 {T}-cell count >100 cells per microliter. {S}pinal reconstructed sagittal planes obtained from chest axial native acquisitions were blindly read by a musculoskeletal imaging specialist. {A}ssessment of the fractured vertebra used {G}enant semiquantitative method. {T}he study end point was the prevalence of at least 1 vertebral fracture.{R}esults:{T}hree hundred ninety-seven subjects were included. {M}edian age was 49.5 years, median smoking history was 30 pack-years, median last {CD}4 count was 584 cells per microliter, and median {CD}4 nadir count was 168 cells per microliter; 90% of subjects had a viral load below 50 copies per milliliter. {A}t least 1 fracture was visible in 46 (11.6%) subjects. {I}n multivariate analysis, smoking 40 packs-years [{OR} = 2.5; 95% {CI}: (1.2 to 5.0)] was associated with an increased risk of vertebral fracture, while {HIV} viral load <200 copies per milliliter [{OR} = 0.3; 95% {CI}: (0.1 to 0.9)] was protective.{C}onclusions:{P}revalence of vertebral fractures on chest {LDCT} was 11.6% in this high-risk population. {S}moking cessation and early introduction of antiretroviral therapy for prevention of vertebral fractures could be beneficial. {C}hest {LDCT} is an opportunity to diagnose vertebral fractures.},
  keywords = {{HIV} ; vertebral fracture ; osteoporosis ; computed tomography ; smoking ; lung cancer},
  booktitle = {},
  journal = {{J}aids.{J}ournal of {A}cquired {I}mmune {D}eficiency {S}yndromes},
  volume = {69},
  numero = {3},
  pages = {299--305},
  ISSN = {1525-4135},
  year = {2015},
  DOI = {10.1097/qai.0000000000000599},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064765},
}