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Koffi A. A., Ahoua Alou L. P., Kabran J. P. K., N'Guessan R., Pennetier Cédric. (2013). Re-visiting insecticide resistance status in Anopheles gambiae from Cote d'Ivoire : a nation-wide informative survey. Plos One, 8 (12), e82387. ISSN 1932-6203

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Lien direct chez l'éditeur doi:10.1371/journal.pone.0082387

Titre
Re-visiting insecticide resistance status in Anopheles gambiae from Cote d'Ivoire : a nation-wide informative survey
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000328735700063
AuteursKoffi A. A., Ahoua Alou L. P., Kabran J. P. K., N'Guessan R., Pennetier Cédric.
SourcePlos One, 2013, 8 (12), p. e82387. p. e82387 ISSN 1932-6203
RésuméInsecticide resistance constitutes a major threat that may undermine current gain in malaria control in most endemic countries. National Malaria Control Programmes (NMCPs) need as much information as possible on the resistance status of malaria vectors and underlying mechanisms in order to implement the most relevant and efficient control strategy. Bioassays, biochemical and molecular analysis were performed on An. gambiae collected in six sentinel sites in Cote d'Ivoire. The sites were selected on the basis of their bioclimatic status and agricultural practices. An. gambiae populations across sites showed high levels of resistance to organochloride, pyrethroid and carbamate insecticides. The kdr and ace-1(R) mutations were detected in almost all sentinel sites with mosquitoes on the coastal and cotton growing areas mostly affected by these mutations. At almost all sites, the levels of detoxifying enzymes (mixed-function oxidases (MFOs), non-specific esterases (NSE) and glutathione-S-transferases (GSTs)) in An. gambiae populations were significantly higher than the levels found in the susceptible strain Kisumu. Pre-exposure of mosquitoes to PBO, an inhibitor of MFOs and NSEs, significantly increased mortality rates to pyrethroids and carbamates in mosquitoes but resistance in most cases was not fully synergised by PBO, inferring a residual role of additional mechanisms, including kdr and ace-1 site insensitivity. The large distribution of resistance in Cote d'Ivoire raises an important question of whether to continue to deploy pyrethroid-based long-lasting insecticidal nets (LLINs) and insecticide residual spraying (IRS) towards which resistance continues to rise with no guarantee that the level of resistance would not compromise their efficacy. Innovative strategies that combine insecticide and synergists in LLINs or spatially LLIN and an effective non-pyrethroid insecticide for IRS could be in the short term the best practice for the NMCP to manage insecticide resistance in malaria vectors in Cote d'Ivoire and other endemic countries facing resistance.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052]
Descr. géo.COTE D'IVOIRE
LocalisationFonds IRD [F B010061421]
Identifiant IRDfdi:010061421
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010061421

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