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Marcombe Sébastien, Paris M., Paupy Christophe, Bringuier C., Yebakima A., Chandre Fabrice, David J. P., Corbel Vincent, Despres L. (2013). Insecticide-driven patterns of genetic variation in the dengue vector Aedes aegypti in Martinique Island. Plos One, 8 (10), e77857. ISSN 1932-6203

Fichier PDF disponiblehttp://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010061246.pdf[ PDF Link ]

Lien direct chez l'éditeur doi:10.1371/journal.pone.0077857

Titre
Insecticide-driven patterns of genetic variation in the dengue vector Aedes aegypti in Martinique Island
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000326029300119
AuteursMarcombe Sébastien, Paris M., Paupy Christophe, Bringuier C., Yebakima A., Chandre Fabrice, David J. P., Corbel Vincent, Despres L.
SourcePlos One, 2013, 8 (10), p. e77857. p. e77857 ISSN 1932-6203
RésuméEffective vector control is currently challenged worldwide by the evolution of resistance to all classes of chemical insecticides in mosquitoes. In Martinique, populations of the dengue vector Aedes aegypti have been intensively treated with temephos and deltamethrin insecticides over the last fifty years, resulting in heterogeneous levels of resistance across the island. Resistance spreading depends on standing genetic variation, selection intensity and gene flow among populations. To determine gene flow intensity, we first investigated neutral patterns of genetic variability in sixteen populations representative of the many environments found in Martinique and experiencing various levels of insecticide pressure, using 6 microsatellites. Allelic richness was lower in populations resistant to deltamethrin, and consanguinity was higher in populations resistant to temephos, consistent with a negative effect of insecticide pressure on neutral genetic diversity. The global genetic differentiation was low, suggesting high gene flow among populations, but significant structure was found, with a pattern of isolation-by-distance at the global scale. Then, we investigated adaptive patterns of divergence in six out of the 16 populations using 319 single nucleotide polymorphisms (SNPs). Five SNP outliers displaying levels of genetic differentiation out of neutral expectations were detected, including the kdr-V1016I mutation in the voltage-gated sodium channel gene. Association tests revealed a total of seven SNPs associated with deltamethrin resistance. Six other SNPs were associated with temephos resistance, including two non-synonymous substitutions in an alkaline phosphatase and in a sulfotransferase respectively. Altogether, both neutral and adaptive patterns of genetic variation in mosquito populations appear to be largely driven by insecticide pressure in Martinique.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052]
Descr. géo.MARTINIQUE
LocalisationFonds IRD [F B010061246]
Identifiant IRDfdi:010061246
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010061246

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