@article{fdi:010061246,
  title = {{I}nsecticide-driven patterns of genetic variation in the dengue vector {A}edes aegypti in {M}artinique {I}sland},
  author = {{M}arcombe, {S}{\'e}bastien and {P}aris, {M}. and {P}aupy, {C}hristophe and {B}ringuier, {C}. and {Y}ebakima, {A}. and {C}handre, {F}abrice and {D}avid, {J}. {P}. and {C}orbel, {V}incent and {D}espres, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}ffective vector control is currently challenged worldwide by the evolution of resistance to all classes of chemical insecticides in mosquitoes. {I}n {M}artinique, populations of the dengue vector {A}edes aegypti have been intensively treated with temephos and deltamethrin insecticides over the last fifty years, resulting in heterogeneous levels of resistance across the island. {R}esistance spreading depends on standing genetic variation, selection intensity and gene flow among populations. {T}o determine gene flow intensity, we first investigated neutral patterns of genetic variability in sixteen populations representative of the many environments found in {M}artinique and experiencing various levels of insecticide pressure, using 6 microsatellites. {A}llelic richness was lower in populations resistant to deltamethrin, and consanguinity was higher in populations resistant to temephos, consistent with a negative effect of insecticide pressure on neutral genetic diversity. {T}he global genetic differentiation was low, suggesting high gene flow among populations, but significant structure was found, with a pattern of isolation-by-distance at the global scale. {T}hen, we investigated adaptive patterns of divergence in six out of the 16 populations using 319 single nucleotide polymorphisms ({SNP}s). {F}ive {SNP} outliers displaying levels of genetic differentiation out of neutral expectations were detected, including the kdr-{V}1016{I} mutation in the voltage-gated sodium channel gene. {A}ssociation tests revealed a total of seven {SNP}s associated with deltamethrin resistance. {S}ix other {SNP}s were associated with temephos resistance, including two non-synonymous substitutions in an alkaline phosphatase and in a sulfotransferase respectively. {A}ltogether, both neutral and adaptive patterns of genetic variation in mosquito populations appear to be largely driven by insecticide pressure in {M}artinique.},
  keywords = {{MARTINIQUE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {10},
  pages = {e77857 [10 ]},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0077857},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061246},
}