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Le Flohic G., Porphyre V., Barbazan Philippe, Gonzalez Jean-Paul. (2013). Review of climate, landscape, and viral genetics as drivers of the Japanese encephalitis virus ecology. Plos Neglected Tropical Diseases, 7 (9), e2208. ISSN 1935-2735

Fichier PDF disponiblehttp://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010061159.pdf[ PDF Link ]

Lien direct chez l'éditeur doi:10.1371/journal.pntd.0002208

Titre
Review of climate, landscape, and viral genetics as drivers of the Japanese encephalitis virus ecology
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000324920800002
AuteursLe Flohic G., Porphyre V., Barbazan Philippe, Gonzalez Jean-Paul.
SourcePlos Neglected Tropical Diseases, 2013, 7 (9), p. e2208. p. e2208 ISSN 1935-2735
RésuméThe Japanese encephalitis virus (JEV), an arthropod-born Flavivirus, is the major cause of viral encephalitis, responsible for 10,000-15,000 deaths each year, yet is a neglected tropical disease. Since the JEV distribution area has been large and continuously extending toward new Asian and Australasian regions, it is considered an emerging and reemerging pathogen. Despite large effective immunization campaigns, Japanese encephalitis remains a disease of global health concern. JEV zoonotic transmission cycles may be either wild or domestic: the first involves wading birds as wild amplifying hosts; the second involves pigs as the main domestic amplifying hosts. Culex mosquito species, especially Cx. tritaeniorhynchus, are the main competent vectors. Although five JEV genotypes circulate, neither clear-cut genotype-phenotype relationship nor clear variations in genotype fitness to hosts or vectors have been identified. Instead, the molecular epidemiology appears highly dependent on vectors, hosts' biology, and on a set of environmental factors. At global scale, climate, land cover, and land use, otherwise strongly dependent on human activities, affect the abundance of JEV vectors, and of wild and domestic hosts. Chiefly, the increase of rice-cultivated surface, intensively used by wading birds, and of pig production in Asia has provided a high availability of resources to mosquito vectors, enhancing the JEV maintenance, amplification, and transmission. At fine scale, the characteristics (density, size, spatial arrangement) of three landscape elements (paddy fields, pig farms, human habitations) facilitate or impede movement of vectors, then determine how the JEV interacts with hosts and vectors and ultimately the infection risk to humans. If the JEV is introduced in a favorable landscape, either by live infected animals or by vectors, then the virus can emerge and become a major threat for human health. Multidisciplinary research is essential to shed light on the biological mechanisms involved in the emergence, spread, reemergence, and genotypic changes of JEV.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde animal [080] ; Sciences du milieu [021]
Descr. géo.ASIE ; AUSTRALIE
LocalisationFonds IRD [F B010061159]
Identifiant IRDfdi:010061159
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010061159

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