Temmam S., Besnard L., Andriamandimby S. F., Foray C., Rasamoelina-Andriamanivo H., Heraud J. M., Cardinale E., Dellagi Koussay, Pavio N., Pascalis Hervé, Porphyre V. (2013). High prevalence of hepatitis E in humans and pigs and evidence of genotype-3 virus in swine, Madagascar. American Journal of Tropical Medicine and Hygiene, 88 (2), p. 329-338. ISSN 0002-9637.
Titre du document
High prevalence of hepatitis E in humans and pigs and evidence of genotype-3 virus in swine, Madagascar
Année de publication
2013
Auteurs
Temmam S., Besnard L., Andriamandimby S. F., Foray C., Rasamoelina-Andriamanivo H., Heraud J. M., Cardinale E., Dellagi Koussay, Pavio N., Pascalis Hervé, Porphyre V.
Source
American Journal of Tropical Medicine and Hygiene, 2013,
88 (2), p. 329-338 ISSN 0002-9637
Hepatitis E virus (HEV) causes an orofecal disease transmitted through poor hygiene environments, contaminated food (mainly pork products), or by contacts with infected animals. Very little data are currently available regarding the disease in the Southwestern Indian Ocean Islands. We report the first sero- and viro-survey for HEV in human and swine in Madagascar. A seroprevalence rate of 14.1% (60 of 427) was measured in slaughterhouse workers. Seroprevalence to HEV in pigs was estimated to 71.2% (178 of 250), strongly suggesting the existence of a zoonotic cycle. Three out of 250 pig livers (1.2%) tested HEY RNA-positive by quantitative polymerase chain reaction. Phylogenetic analyses based on 1-kb sequences of the ORF 2-3 identified these viruses as HEV genotype 3. Sequences clustered in a distinct Malagasy sub-clade, possibly representative of a new sub-genotype, for which the date of emergence was estimated around 1989. Further studies are needed to confirm other transmission routes of HEV to humans, especially through non-zoonotic cycles.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
MADAGASCAR
Localisation
Fonds IRD [F B010059013]
Identifiant IRD
fdi:010059013
