Bibollet-Ruche Frédéric, Brengues Cécile, Galat Luong Anh, Galat Gérard, Pourrut Xavier, Vidal Nicole, Veas Francisco, Durand J.P., Cuny Gérard. (1997). Genetic diversity of simian immunodeficiency viruses from west African green monkeys : evidence of multiple genotypes within populations from the same geographical locale. Journal of Virology, 71 (1), p. 307-313. ISSN 0022-538X.
Titre du document
Genetic diversity of simian immunodeficiency viruses from west African green monkeys : evidence of multiple genotypes within populations from the same geographical locale
Journal of Virology, 1997,
71 (1), p. 307-313 ISSN 0022-538X
High simian immunodeficiency virus (SIV) seroprevalence rates have been reported in the different green monkey (AGM) subspecies. Genetic diversity of these viruses far exceeds the diversity observed in the other lentivirus-infected human and nonhuman primates and is thought to reflect ancient introduction of SIV in the AGM population. We investigate here genetic diversity of SIVagm in wild-living AGM populations from the same geographical locale (i.e., sympatric population) in Senegal. For 11 new strains, we PCR amplified and sequenced two regions of the genome spanning the first tat exon and part of the transmembrane glycoprotein. Phylogenetic analysis of these sequences shows that viruses found in sympatric populations cluster into distinct lineages, with at least two distinct genotypes in each troop. These data strongly suggest an ancient introduction of these divergent viruses in the AGM population. (Résumé d'auteur)
